载药淀粉微球的制备及可控降解研究  

Research on starch microspheres as drug carriers prepared and controllable degradation

作　　者：王海峰[1] 李仲谨[1] 黄永如[1] 赵阳[1] 杨祥龙[1] 

机构地区：[1]陕西科技大学化学与化工学院,教育部轻化工助剂化学与技术重点实验室,西安710021

出　　处：《食品科技》2009年第11期248-251,256,共5页Food Science and Technology

基　　金：国家自然科学基金资助项目(50573046);陕西省科学技术研究发展计划项目(2006K08-G11);陕西科技大学研究生创新基金

摘　　要：以可溶性淀粉溶液为水相,环己烷和氯仿为油相,m(Span60)∶m(Tween60)=2∶1为乳化剂,N,N′-亚甲基双丙烯酰胺(MBAA)为交联剂,K2S2O8-NaHSO3为引发体系,在反相悬浮体系中合成载药淀粉微球。采用正交设计实验法,考察了影响微球粒径的因素;在人工胃液和肠液中进行了降解实验。结果表明,影响微球平均粒径的主要因素是淀粉溶液浓度和搅拌速度,调节这些因素,可以在一定程度上实现对微球粒径的控制;控制微球在胃液3h结构稳定,肠液9h内平稳降解的最佳合成工艺是:N,N′-亚甲基双丙烯酰胺质量分数为0.6%,v(水):v(油)=1∶5,淀粉溶液浓度20%,搅拌转速900r/min,引发剂浓度为5.5%,在此工艺下合成的淀粉微球平均粒径是15.5μm。The starch microspheres as drug carriers were synthesized from soluble starch through Inverse Suspension Polymerization, cyclohexane and chloroform were used as the oil phase, Span 60 and Tween 60 as the surfactant, N,N＇-methylenebisacrylamide as the crosslinking agent, initiated by potassium persulphate- sodium bisulfite. The influence of preparation conditions on their particle size was investigated by orthogonal experiments; Microspheres were degraded by using artificial gastric juice and artificial intestinal juice in vitro. The results show that the average particle size of starch microspheres is mainly affected by starch concentration and agitation speed. By regulating these factors, it is possible to control average diameter of starch microspheres. The optimal synthesis process for maintaining microspheres stable structure 3 hours in artificial gastric juice and smooth degradation 9 hours in artificial intestinal juice is as follows： mass fraction of MBAA is 0.6%, v（water）： v（oil）=1：5, starch concentration is 20%, stirring speed is 900 r/min, initiator concentration is 5.5%. Average size of the starch microspheres is 15.5 μm.

关 键 词：淀粉微球 制备 正交设计 可控降解 

分 类 号：TS236.9[轻工技术与工程—粮食、油脂及植物蛋白工程]