依达拉奉对外伤性脑内出血患者血浆ET-1和CGRP影响的临床探讨  

Study on the Effect of Edaravone on Changes of Plasma ET-1 and CGRP Levels in Patients with Traumatic Intracerebral Hemorrhage

作　　者：张春银[1] 蔡亮[1] 郭佳[1] 官明[2] 甘西伦[1] 

机构地区：[1]泸州医学院附属医院核医学科,646000 [2]泸州医学院附属医院神经外科,646000

出　　处：《放射免疫学杂志》2009年第4期324-326,共3页Journal of Radioimmanology

摘　　要：目的:探讨外伤性脑内出血患者血浆ET-1和CGRP变化以及依达拉奉治疗对血浆ET-1和CGRP的影响。方法:80例外伤性脑内出血患者随机分为依达拉奉组与常规治疗组,另取30例健康人作为对照组。用放射免疫分析测定外伤性脑内出血患者依达拉奉治疗前后血浆ET-1、CGRP含量。结果:依达拉奉组和常规治疗组治疗前血浆ET-1显著增高,治疗后明显下降,治疗后血浆ET-1降低常规治疗组明显少于依达拉奉组(P<0.01);依达拉奉组和常规治疗组治疗前血浆CGRP显著降低,治疗后明显升高,治疗后血浆CGRP增加,依达拉奉组明显高于常规治疗组(P<0.01)。结论:外伤性脑内出血患者血浆ET-1水平显著升高,CGRP水平显著降低;早期应用依达拉奉可显著降低ET-1和提高CGRP水平,初步研究显示,依达拉奉具有脑保护作用。伤后早期应用依达拉奉可改善病人预后。Objective To investigate the effect of edaravone treatment on plasma ET-1 and CGRP levels changes in patients with traumatic intracerebral hemorrhage.Methods Plasma ET-1 and CGRP levels were measured with RIA in 40 patients with traumatic intracerebral hemorrhage both before and after treatment with 60mg of edaravone i.v.q.d.for 5 days,40 patients both before and after treatment with conventional treatment only（without edaravone） and 30 controls（once only）.Results The plasma ET-1 levels were significantly increased in all the patients at admission than those in controls.After treatment,the levels in all the patients dropped significantly,but the levels were significantly lower in edaravone-treated patients than those in non-edaravone-treated patients（P〈0.01）.The reverse was true for plasma CGRP levels.Conclusion Edaravone treatment could correct the abnormal plasma ET-1 and CGRP levels in patients with traumatic intracerebral hemorrhage and might be beneficial to recovery.

关 键 词：脑内出血 脑损伤 依达拉奉 内皮素 降钙素基因相关肽 

分 类 号：R971.92[医药卫生—药品] R747.2[医药卫生—药学]