复方黄连涂膜剂中盐酸小檗碱经皮吸收研究  

Study on Plastics Transdermal Absorption of Berberine Hydrochloride of Complex Prescription Coptis chinensis

作　　者：施薇[1,2] 刘志强[1] 王淑敏[3] 皮子凤[1] 

机构地区：[1]中国科学院长春应用化学研究所,吉林长春130022 [2]吉林农业大学中药材学院,吉林长春130118 [3]长春中医药大学药学院,吉林长春130117

出　　处：《时珍国医国药》2009年第11期2696-2697,共2页Lishizhen Medicine and Materia Medica Research

基　　金：中国科学院知识创新工程重要方向项目(No.KGCX2-SW-213-6)

摘　　要：目的研究氮酮对盐酸小檗碱的体外透皮吸收的影响,为黄连复方涂膜剂透膜吸收促进剂的选择和生产质量控制提供依据。方法以裸鼠皮肤为试验屏障,利用ZTY智能透皮实验仪和高效液相色谱(HPLC)检测法,研究氮酮与冰片联合使用时对盐酸小檗碱透皮吸收的影响。结果当一定量的冰片与浓度分别为0%,2%,5%的氮酮联合使用时,盐酸小檗碱的透皮吸收速率常数分别为62.591,52.927,60.622μg.cm-2.h-1。结论冰片与不同浓度的氮酮联合使用时,氮酮与冰片有一定的相互抑制作用,氮酮浓度为0%时,有最大的透皮吸收速率常数。Objective To study the effects of azone on the percutaneous of berberine hydrochloride in vitro so as to provide experimental basis for complex prescription Coptis chinensis plastics to choose absorb promoter and control production quality.Methods With the skin of nude mice as the barrier,ZTY intelligence permeation skin tester and detection of HPLC were used to study the effects of coalition utilization of azone and borneol for percutaneous absorption of berberine hydrochloride in vitro.Results The rate constants of berberine hydrochloride were 62.591,52. 927 and 60.622 μg · cm^-2 · h^-1 respectively when azone and bomed of 0,2% ,5% were used together. Conclusion Azone with different concentration and bomel inhibit each other when they are combinedly used. The absorption rate is maximum when azone is 0%.

关 键 词：涂膜剂 透皮吸收 高效液相色谱 盐酸小檗碱 

分 类 号：R284.1[医药卫生—中药学]