苦石莲对小鼠急性实验性肝损伤的保护作用  

Protective Effect of Caesalpinia minax Hance against Acute Liver Injury in Mice

作　　者：郭美仙[1] 刘明[1] 施贵荣[1] 何正春[1] 刘晓波[1] 

机构地区：[1]大理学院.药学院,云南大理671000

出　　处：《时珍国医国药》2009年第11期2786-2787,共2页Lishizhen Medicine and Materia Medica Research

基　　金：云南省教育厅资助项目(No.2005KY416440)

摘　　要：目的研究苦石莲对D-半乳糖胺(D-GalN)、酒精所致小鼠急性实验性肝损伤的影响。方法苦石莲总提取物灌胃给药7 d后,用D-GalN、酒精导致小鼠急性实验性肝损伤,检测小鼠血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性和肝脏系数。结果苦石莲对小鼠急性实验性肝损伤血清ALT、AST活性和肝脏系数均有明显抑制作用(P<0.01,P<0.05)。结论苦石莲对D-GalN、酒精所致小鼠急性实验性肝损伤具有一定的保护作用。Objective To study the protective effect of Caesalpinia minax Hance against acute liver injury in mice made by D-GalNactosamine and alcohol.Methods The acute hepatic injury model made by D-GalNactosamine and alcohol after i.g.mice the Caesalpinia minax Hance for 7 days,then the activities of alanine aminotransferase（ALT） and aspartate aminotransferase（AST） in serum were examined.Results Caesalpinia minax Hance could decrease the liver index（P〈0.01,P〈0.05） and the activities of ALT and AST（ P 〈 0. 01, P 〈 0.05 ） in serum. Conclusion Caesalpinia minax Hance has protective effect against a- cute liver injury in mice.

关 键 词：苦石莲 实验性肝损伤 

分 类 号：R285.5[医药卫生—中药学]