包载甲氨蝶呤的聚乙交酯丙交酯纳米颗粒的制备与体外释药机制研究  

Preparation and Mechanism Study on Release in vitro of Methotrexate Loaded Poly(Lactic-co-glycolic) Nanoparticles

作　　者：郑明彬[1] 龚萍[2] 杨雪梅[1] 吴喜仁[1] 梅俊[1] 

机构地区：[1]广东医学院化学教研室,广东东莞523808 [2]中国科学院深圳先进技术研究院生物医学与健康工程研究所,广东深圳518054

出　　处：《时珍国医国药》2009年第11期2812-2813,共2页Lishizhen Medicine and Materia Medica Research

基　　金：广东省科技计划项目(No.2007B01060038);广东省科技计划项目(No.2006B14701008);广东医学院青年基金(No.XQ0718)

摘　　要：目的制备包载甲氨蝶呤(MTX)的聚乙交酯丙交酯(PLGA)纳米颗粒并研究体外释药机制。方法采用溶剂挥发法制备包载MTX的PLGA纳米颗粒,对其形貌、大小进行表征,测定体外释药曲线,并采用药学模型进行拟合。结果纳米颗粒平均粒径为175.9nm,具有明显的缓释作用,释药行为最符合双相动力学方程。结论该研究为开发MTX的新剂型提供了实验依据。Objective To prepare methotrexate（MTX） loaded poly（lactic-co-glycolic）（PLGA） nanoparticles and investigate the mechanism on release in vitro.Methods MTX-loaded nanoparticles were prepared by emulsion solvent evaporation method.The morphology and size of nanoparticles were studied,and in vitro release curve was measured.Moreover,the release data were fitted with different mathematical models.Results The mean size of nanoparticleas was 175.9nm,and the obtained nanoparticles showed evidently sustained release effect. The release behavior of MTX loaded nanoparticles was well fitted to the double phase dynamic equation. Conclusion The work provides an experiment basis for the development of novel ideal administration of MTX.

关 键 词：甲氨蝶呤 聚乙交酯丙交酯 纳米颗粒 拟合 

分 类 号：R283[医药卫生—中药学]