成人隐匿性自身免疫性糖尿病患者血清IL-10、TGF-β水平及其与胰岛β细胞功能的关系  

Expressions of IL-10 and TGF-β and their relations with Islet beta cell function in adults with latent autoimmune diabetes

作　　者：范右飞[1] 王静[1] 杨松[1] 庄峰[1] 高聆[1] 管庆波[1] 赵家军[1] 

机构地区：[1]山东大学附属省立医院内分泌科,济南250021

出　　处：《山东大学学报（医学版）》2009年第10期15-18,共4页Journal of Shandong University:Health Sciences

基　　金：山东省医药卫生科技发展计划项目(1999CA1CDB1)

摘　　要：目的探讨成人隐匿性自身免疫性糖尿病(LADA)患者外周血细胞因子白介素-10(IL-10)、转化生长因子-β(TGF-β)水平变化及其与胰岛β细胞功能的关系。方法以双抗夹心ELISA法检测30例LADA(LADA组)、30例2型糖尿病(T2DM组)、30例正常对照(正常对照组)外周血血清中IL-10、TGF-β水平,同时应用HOMA公式计算胰岛素释放指数(HOMA-IS)。结果LADA组的IL-10水平低于T2DM组(P<0.05),高于正常对照组(P<0.05)。LADA组的TGF-β水平与T2DM组相比,差异无统计学意义(P>0.05)。IL-10水平与患者LnHOMA-IS成正相关(r=0.314,P=0.017)。结论LADA患者体内存在细胞免疫功能失衡,不能有效地维持自身的免疫耐受,可能是LADA患者胰岛β细胞功能损害的主要因素。Objective To investigate changes and significance of IL-10 and TGF-β in the peripheral blood of latent autoimmune diabetes in adults（LADA）patients.Methods 30 LADA patients,30 type 2 diabetic（T2DM）patients and 30 volunteers were involved in this study.Levels of IL-10 and TGF-β in the peripheral blood were determined by ELISA.A homeostasis model assessment of insulin secretion（HOMA-IS）was used to estimate insulin function.Results IL-10 in the LADA group was lower than that in the T2DM group but was higher than that in the control group.TGF-βhad no significant difference between the LADA group and the T2DM group.IL-10 had a positive correlation with LnHOMA-IS（r=0.314,P=0.017）.Conclusion Our results suggest that an imbalance of cell immunity exists in LADA patients,which can not maintain the autoimmune tolerance and promote the generation and development of LADA,and is the main reason for impaired islet beta cell functions in LADA patients.

关 键 词：成人 隐匿性自身免疫性糖尿病 白介素-10 转化生长因子-β 

分 类 号：R587.1[医药卫生—内分泌]