现有乙型肝炎多表位疫苗在中国人群中的理论免疫效果评价  

Valuation of theoretical immune response status of HBV multi-epitope vaccines in existence in the population of China

作　　者：薛皓[1] 张颖倩[1] 薛付忠 马春红[1] 

机构地区：[1]山东大学医学院免疫学研究所,济南250012 [2]公共卫生学院流行病与卫生统计研究所,济南250012

出　　处：《山东大学学报（医学版）》2009年第10期114-117,121,共5页Journal of Shandong University:Health Sciences

摘　　要：目的预测现有乙型肝炎(HBV)多表位疫苗在中国的理论免疫应答率,并做出评价。方法利用"中国多表位疫苗设计的HLA-Ⅰ积累表型频率空间预测系统"计算现有的HBV表位DNA疫苗所涉及的HLA-A、B限制性表位组合在中国人群中的累积表型频率(CPF),得出理论免疫应答率,并绘制CPF预测等值线图,给出评价。结果现有各HBV多表位疫苗对中国人群的理论免疫应答率偏低,仅较多表位组合的疫苗理论免疫应答率高。现有HBV多表位疫苗存在不同方面的问题:大部分此类疫苗对中国人群的理论免疫应答率低;少数此类疫苗理论免疫应答率高,但为较多表位的组合,不符合多表位疫苗设计的原则,并没有用最少的表位组合达到最高的免疫应答率。结论现有的几种主要的HBV多表位疫苗并不能较好地符合中国人群的特点,效果不佳。Objective To predict the theoretical immune response status of HBV multi-epitope vaccines and valuate its effect in the population of China.Methods Cumulative phenotypic frequency（CPF）of HBV multi-epitope vaccines was calculated by the system,Forecasting System of Theoretical Immune Response Rate of HLA-A-B Loci Restricted Multi-epitope Vaccine in the Chinese Population,and thus their theoretical responder status in the Chinese population was evaluated.Results The problems of HBV multi-epitope vaccines had already been found in the two aspects.On the one hand,the theoretical responder status of most HBV multi-epitope vaccines are low in the Chinese population,on the other hand,vaccines with high theoretical responder status are combinations of five or more epitopes,which is unnecessary and uneconomical.Conclusion HBV multi-epitope vaccines have already been observed do not achieve the ideal level,and new HBV multi-epitope vaccines should be worked on.

关 键 词：肝炎 乙型 多表位疫苗 DNA疫苗 空间预测系统 HLA-Ⅰ积累表型频率 

分 类 号：R512.6[医药卫生—内科学]