系统性红斑狼疮的高脂血症与肝损害相关性研究  

Analysis for Hyperlipemia Correlation with Hepatic Involvement in Systemic Lupus Erythematosus

作　　者：李敏[1] 杨闵[1] 岑筱敏[1] 杨南萍[1] 石连杰[1] 叶杨[1] 钟雪[1] 赵臻怡[1] 李江涛[2] 

机构地区：[1]四川大学华西医院风湿免疫科,四川成都610041 [2]四川省宜宾市第一人民医院风湿免疫科,四川宜宾644000

出　　处：《华西医学》2009年第8期2060-2062,共3页West China Medical Journal

摘　　要：目的:比较伴或不伴高脂血症的系统性红斑狼疮(SLE)患者的狼疮性肝损害的构成比例,了解高脂血症与狼疮性肝损害的相关性。方法:收集SLE患者100例,根据高脂血症和狼疮性肝损害的诊断标准,将患者分为高脂血症组,非高脂血症组和肝损害组,非肝损害组,收集其相关临床数据进行比较分析。结果:1.高脂血症组发生肝损害的比例高于非高脂血症组(χ2=9.908,P=0.002);2.血脂水平中甘油三酯与γ-GT(r=0.366,P=0.000),碱性磷酸酶(r=0.241,P=0.018),强的松剂量(r=0.31,P=0.006),24 h尿蛋白定量(r=0.273,P=0.007)相关;TC与24 h尿蛋白定量(r=0.273,P=0.007)相关;HDL与γ谷氨酸转肽酶(r=-0.233,P=0.022),碱性磷酸酶(r=-0.265,P=0.009)相关;3.SLE活动组出现高脂血症的比例高于非活动组(χ2=6.986,P=0.008)。结论:长期的高脂血症可导致或加重SLE患者肝功能损害,高脂血症是狼疮性肝损害的危险因素之一。Objective：To compare the hepatic involvement constituent ratio in systemic lupus erythematosus（SLE） with hyperlipemia and non-hyperlipemia,and to analyze the correlation between hyperlipemia and hepatic involvement in SLE.Methods：One hundred cases of SLE were collected and divided into four groups according to the diagnostic criteria for hyperlipemia and hepatic involvement in SLE：hyperlipemia,non-hyperlipemia,hepatic involvement and non-hepatic involvement groups.The clinical data from these groups were analyzed and compared.Results：1.The ratio of the hepatic involvement was higher in hyperlipemia group than in non-hyperlipemia group（χ^2=9.908,P=0.002）.2.TG was correlated with γ-GT（r=0.366,P=0.000）,ALP（r=0.241,P=0.018）,the dosage of prednisone（r=0.31,P=0.006）,the quantitation of urine protein in 24 hours（r=0.273,P=0.007）;TC was correlated with the quantitation of urine protein in 24 hours（r=0.273,P=0.007）;HDL was correlated with γ-GT（r=-0.233,P=0.022）,ALP（r=-0.265,P=0.009）;3.the disease activity in SLE was correlated with hyperlipemia（χ^2=6.986,P=0.008）.Conclusion：The prolonged hyperlipemia may occur or aggravate hepatic involvement in SLE,and hyperlipemia is a risk factor for hepatic involvement in SLE.

关 键 词：高脂血症 肝损害 红斑狼疮 系统性 

分 类 号：R593.241[医药卫生—内科学] R589.2[医药卫生—临床医学]