雷公藤多苷片不良反应的回顾性分析  

Analysis of Adverse Drug Reaction of Glucoside Tripterygium Total

作　　者：江云鸥[1] 陈倩岚[1] 张志勇[1] 

机构地区：[1]四川大学华西医院药剂科,四川成都610041

出　　处：《华西医学》2009年第9期2357-2359,共3页West China Medical Journal

摘　　要：目的:减少雷公藤多苷片引起的严重不良反应发生,保证用药安全。方法:通过检索雷公藤多苷片不良反应相关文献,筛选个案或典型病例报告,分析该类不良反应的临床特征。结果:64例个案病例中,不良反应累及器官或系统以血液系统为主、其次为生殖系统、泌尿系统和肝胆系统,大多较轻微,为一过性,停药后对症治疗可以恢复,但长期或大剂量服用可能导致严重的不良反应。结论:雷公藤多苷片所致不良反应与服药时间相关,可累积多个系统,建议根据病情严格控制服药剂量,并且在服药前和服药期间检查血、尿常规和肝肾功能。Objective： To decrease the prevalence of severe ADR of glucoside tripterygium total （GTT）, and use GTT safely. Methods： Related data were retrieved, screened and analyzed. Results： Of the 64 ADR cases, the majority of ADR - involved systemic lesions were injury of hematological system, followed by the injury of the urinary system and liver system. The most ADR cases were not severe, and the patients could recover after drug discontinuance and symptomatic treatment. But severe ADR could be caused after taking the GTT at larger dosages or in long time. Conclusion： ADR of GTT is related to the course of treatment. Suggest pay more attention to the daily dosage and total dosage and check blood, urine and the function of kidney and liver before and after the drug administration.

关 键 词：雷公藤多苷片 不良反应 文献分析 

分 类 号：R286.0[医药卫生—中药学] R595.3[医药卫生—中医学]