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作 者:陈航[1] 高燕[1] 贾海红[1] 张金超[2] 孙静[1] 李美朝[3]
机构地区:[1]河北大学附属医院肾脏内科,河北保定071000 [2]河北大学化学与环境科学学院化学生物学试验室,河北保定071002 [3]保定市第五医院内科,河北保定071051
出 处:《中国现代医学杂志》2009年第19期2989-2990,2994,共3页China Journal of Modern Medicine
基 金:河北大学附属医院博士基金课题(No:2005011)
摘 要:目的了解肾病综合征患者停用糖皮质激素(glucocorticoid,GC)后的骨质疏松恢复情况。方法应用双能X线骨密度仪(DEXA)检测79例肾病综合征患者停用糖皮质激素1年后腰椎和股骨颈骨密度情况,记录患者的年龄、性别、体重指数、吸烟史、应用糖皮质激素的时间和累积剂量;分析影响骨质变化的因素。结果79例患者中骨密度正常者占61%,骨量减少者占39%。应用糖皮质激素时间越长的患者骨质恢复相对较慢。结论肾病综合征患者停用激素1年后骨密度可以恢复,且应用激素时间短者恢复快。[ Objective] To investigate the state of bone mineral density (BMD) after stopping glucocorticoid treatment in patients with nephritic syndrome, and analyze the factors influencing the BMD. [Methods] 79 patients with nephritic syndrome after stopping glucocortieoid therapy (one year later) were observed. BMD in the lumbar spine and the femoral neck were measured by dual-energy X-ray absorptiometry (DEXA). Age, sex, body-mass-index, smoking history, the time and accumulative dose of glucocorticoid were recorded, the factors that influence the BMD were analyzed. [Results] 79 patients were included in this study. Among them, normal BMD and osteopenia were found in 48 (61%) and 31(39%) patients respectively. The speed of removing nomal BMD with receving longer time glucoeorticoid treatment is significant slower compared with receving shorter time glueocorticoid treatment. [ Conclusion] BMD in patients with nephritic syndrome after stopping glueocorficoid therapy (one year later) could be removed, the shorter the patients reeeved glucocorticoid therapy, the faster the BMD reeoved.
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