黄芩-柴胡药对提取工艺的正交优选  

Study on the extraction process of Radix Scutellariae and Radix Bupleuri

作　　者：余晓东[1] 刘田云[1] 孙付军[2] 刘逢芹[1] 

机构地区：[1]山东大学附属千佛山医院,山东济南250014 [2]山东中医药研究院,山东济南250014

出　　处：《中国医院药学杂志》2009年第22期1907-1909,共3页Chinese Journal of Hospital Pharmacy

基　　金：山东省自然科学基金项目(编号:Y2006C84)

摘　　要：目的:优选黄芩-柴胡"药对"的最佳提取工艺。方法:采用正交设计法,以高效液相色谱法测定黄芩苷和柴胡皂苷a、d的含量,筛选出"药对"的优化提取条件。结果:黄芩-柴胡"药对"最佳提取工艺为8倍量70%乙醇回流提取2次,每次1h。结论:该提取工艺稳定性、重复性较好,以"药对"药效成分为考察指标客观可行,为指导临床合理用药、提高药效提供实验室依据。OBJECTIVE To optimize the extraction process of the combination of the two herbs. METHODS The orthogonai test was employed for selecting the optimum of extraction technology, by the contents of Baicalin and saikosaponin for the evaluation, screen out the best extraction process. RESULTS The best extraction process was： 8 times 70% alcoholextracted for 2 times,each time for 1 h. CONCLUSION This method is stable, replicable and feasible, which can be used for industrial production.

关 键 词：药对 正交试验 黄芩苷 柴胡皂苷 

分 类 号：R284[医药卫生—中药学]