NS398对缺氧缺血性脑损伤新生鼠远期学习记忆能力的干预效应  

Long-term learning and memory capacity effects on neonatal HIBD rats after NS398 intervened

作　　者：温恩懿[1] 廖伟[1] 赵聪敏[1] 

机构地区：[1]第三军医大学新桥医院儿科,重庆400037

出　　处：《重庆医学》2009年第22期2793-2794,共2页Chongqing medicine

摘　　要：目的研究新生大鼠缺氧缺血性脑损伤(HIBD)时应用选择性环氧合酶-2(COX-2)抑制剂NS398干预后的远期学习记忆能力干预效应。方法于制备新生大鼠左脑的HIBD模型后30min,应用腹腔注射NS398 20mg/kg,同时建立未注射HIBD组及假手术组,于HIBD后28d,用Morris水迷宫实验及穿梭箱实验测试大鼠的远期学习记忆能力。结果28d后HIBD组远期学习记忆能力显著低于假手术组;NS398组远期学习记忆能力优于HIBD组。结论应用选择性COX-2抑制剂NS398可以改善HIBD新生鼠的远期学习记忆能力。Objective To study long-term learning and memory capacity effects on the neonatal hypoxic-ischemic brain damage （HIBD） rats after injected selective COX 2 inhibitor NS398 intervened. Methods Intraperitoneal injected with NS398 after the model of HIBD Wistar rats was established,the Morris water maze test and shuttle box test in rats were used to research effects of long-term learning and memory at 28d after hypoxic-ischemic damaged. HIBD group and control group also counted at a same way. Results After statistical comparison, HIBD group was significantly lower than control group in long-term learning and memory ability,and NS398 group was superior to HIBD group. Conclusion Application of selective COX-2 inhibitor NS398 can improve long-term learning and memory ability in neonatal HIBD rats.

关 键 词：缺氧缺血性脑损伤 选择性COX-2抑制剂 学习记忆能力 新生鼠 

分 类 号：R722.1[医药卫生—儿科]