学龄前期儿童胰岛素样生长因子-1、生长激素释放肽水平及其与生长关系的研究  

Serum level of insulin-like growth factor-1 and the plasma level of Ghrelin in 2-7 years old children and their relationship with growth and development

作　　者：李治鹏[1] 许龙柱[2] 毛萌[2] 

机构地区：[1]四川大学华西医院金卡病房,成都610041 [2]四川大学华西第二医院儿科,成都610041

出　　处：《重庆医学》2009年第22期2844-2846,共3页Chongqing medicine

摘　　要：目的探讨胰岛素样生长因子-1(IGF-1)和生长激素释放肽(Ghrelin)水平在学龄前期适于胎龄儿(AGA)儿童、小于胎龄儿(SGA)儿童、非SGA身材矮小儿童生长发育中的作用。方法筛选符合要求的SGA组、健康对照组和非SGA身材矮小组的学龄前期儿童,进行IGF-I和Ghrelin水平测定并分析相关性。结果(1)Ghrelin水平与年龄、性别均无相关性,IGF-1水平与年龄有相关性;(2)SGA组血清IGF-1水平与健康对照组比较差异无统计学意义;(3)SGA组Ghrelin水平与健康对照组比较差异无统计学意义。结论SGA儿童生长发育落后于正常儿童,但两者IGF-1和Ghrelin水平没有差异。Objectives To explore the role of insulin-like growth factor-1（GF-1） and Ghrelin in the growth and development of 2 - 7 years old children born small for gestational age and non-SGA stunting children. Methods Twenty normal children born appropriate for gestational age and 30 children born small for gestational age and 30 stunting children born not small for gestational age were included. We measured the serum level of IGF-1 and the plasma level of Ghrelin of the three groups. And the results were ana- lyzed by t-test,Х^2-test. Results （1）There were no relationships between the level of plasma Ghrelin of the 2-7 year-aged children and their gender or ages. There were some relationships between the level of IGF-1 and the ages. （2）There was no significant difference in the serum level of IGF-1 between the control and SGA group. （3）There was no significant difference in the serum level of Ghrelin between the control and SGA group. Conclusion The level of IGF-1 and Ghrelin showed no significant difference between the SGA and control children at the age of 2-7 years old.

关 键 词：SGA IGF-1 GHRELIN 生长发育 

分 类 号：R179[医药卫生—妇幼卫生保健] R446.112[医药卫生—公共卫生与预防医学]