淮安市食管鳞癌患者血清^1H NMR波谱初步研究  

Primary Study of ^1H NMR Fingerprint of Sera from Huai＇an City Patients with Esophageal Squamous Cell Carcinoma

作　　者：孙晓阳[1] 姜玉章[1] 史昆波[2] 

机构地区：[1]南京医科大学附属淮安第一人民医院,江苏淮安223300 [2]淮阴师范学院分析测试中心,江苏淮安223300

出　　处：《分析测试学报》2009年第11期1295-1298,1303,共5页Journal of Instrumental Analysis

基　　金：淮安市科委基金资助项目(HAS08010)

摘　　要：测试了30例正常人血清和60例淮安市食管鳞癌患者血清的氢核磁共振波谱。观察到正常人血清的共振峰主要集中在化学位移δH（ppm）1．00～5．00，构建了正常人血清的^1H NMR指纹图谱。同时将食管鳞癌患者血清^1H NMR与正常人血清^1H NMR进行比较，发现食管鳞癌患者与正常人血清样品在δH 1．0～1．2和δH 3．0～3．8（如δH 3．25、3．23、3．36、3．41、3．43）存在一定的差异波峰，即食管鳞癌的可能特征峰。表明借助于^1H NMR特征峰有助于食管鳞癌的早期诊断。The serum samples obtained from 60 preoperative patients coming from Huai＇an city with esophageal squamous cell carcinoma （ESCC） and 30 healthy controls were analyzed by ^1H-nuclear magnetic resonance spectroscopy（^1H-NMR）. The result indicated that ^1H-NMR characteristic peaks of the healthy controls were concentrated in the range of δH 1.00 --5. 00. A characteristic fingerprint spectra in healthy controls was obtained. Comparing with the ^1H-NMR spectra of the healthy controls and the ESCC patients, those of the patients with ESCC showed a certain difference in the range of ^1H 1.0-1.2 and δH 3.0-3.8, e.g. δH 3.25, 3. 23, 3. 36, 3. 41, 3.43. Therefore, it was helpful for early diagnosis of ESCC by ^1H NMR spectra of serum from patients.

关 键 词：血清 氢核磁共振波谱 指纹图谱 食管鳞癌 

分 类 号：O482.532[理学—固体物理] Q279[理学—物理]