瘀浊清颗粒的抗疲劳作用及其机理  

Anti-fatigue Effect of Yuzhuoqing Granules and its Mechanism

作　　者：刘德桓[1] 郭伟聪[1] 王秀宝[1] 陈文鑫 林炳辉[3] 倪峰[3] 

机构地区：[1]福建中医学院附属泉州市中医院 [2]福建泉州市医药研究所 [3]福建中医药研究院

出　　处：《世界中医药》2009年第6期338-339,共2页World Chinese Medicine

基　　金：福建省中医药科研重点项目(wzzx0602);福建省泉州市科研重点项目(2005Z21)

摘　　要：目的:观察瘀浊清颗粒对小鼠的抗疲劳作用,并探讨其机制。方法:选取昆明种小鼠40只,按体重随机分成空白组(生理盐水)、阳性对照组(太子参提取液)和瘀浊清颗粒低剂量、高剂量组4组,灌胃给药10天。小鼠尾部负荷10%体重的铅丝,置水中游泳并开始计时,观察小鼠的游泳时间。结果:在抗疲劳实验中,瘀浊清颗粒低、高剂量组小鼠负重游泳时间的均值与空白对照组比较差异有显著性(P<0.05,P<0.01);高剂量组的均值与阳性对照组比较差异有显著性(P<0.05)。结论:瘀浊清颗粒能延长小鼠负重游泳时间,具有增加耐力和抗疲劳的作用。Objective ： To observe the anti-fatigue effect of Yuzhuoqing Granules and its mechanism on rats. Methods ： Forty mice of Kunming breed randomly allocated, received lavage respectively with physiological saline, Princens extraction, low dose and high dose of the granules for 10 days. To mount lead as heavy as 10% body weight onto the mice＇ tails, and observe the swimming duration till mice sank. Results ： Both granule-treated groups showed significantly longer swimming duration than the blank group （ P 〈 0. 05, P 〈 0.01 ） ; While the mean time value of the high dose group was significantly longer than that of the positive control group （ P 〈 0. 05 ）. Conclusion：Having prolonged swimming duration in the experiment, it was concluded that Yuzhuoqing Granules can improve physical endurance and fight fatigue.

关 键 词：抗疲劳/中医药疗法 @瘀浊清颗粒 

分 类 号：R285.5[医药卫生—中药学] R242[医药卫生—中医学]