血脂清对血脂异常大鼠降脂作用及对CRP、IL-6、ox-LDL水平的影响  

Effects of Xuezhiqing on CRP、IL-6 and ox-LDL in Rats with Dyslipidemia

作　　者：潘涛[1] 顾勤[1] 

机构地区：[1]南京中医药大学第一临床医学院

出　　处：《中西医结合心脑血管病杂志》2009年第11期1302-1303,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：江苏省教育厅自然科学基金项目(No.05KJB360096)

摘　　要：目的探讨血脂清对血脂异常大鼠的调脂作用及抗动脉硬化机制。方法将SD大鼠随机分为正常组、实验对照组、血脂清治疗组、瑞舒伐他汀治疗组。应用高脂饲料造模,比较其干预前后血脂水平及炎症因子C-反应蛋白(CRP)、白介素-6(IL-6)和氧化低密度脂蛋白胆固醇(ox-LDL)水平。结果血脂清可以显著降低血脂异常大鼠低密度脂蛋白胆固醇(LDL-C)及CPR、IL-6、ox-LDL水平,低剂量即显示其治疗作用。血脂清与瑞舒伐他汀的作用组间无统计学意义(P>0.05)。结论中医清热化湿、涤痰消浊法可以通过改善血脂异常、抑制炎症因子、抗脂质过氧化,达到调节血脂、防治动脉硬化的治疗作用。Objective To explore the regulating lipid and anti - atherosclerosis effects of Xuezhiqing on rats with dyslipidemia. Methods Sprague-Dawley rats were randomly divided into four groups：Normal group,control group,Xuezhiqing treatment group, and rosuvaslatin treatment group. Rat models were established by feeding with high fat diet. The level of lipid,C - reactive protein （CRP） ,interleukin -6（IL -6）and oxidized low -density lipoprotein（ox -LDL） were detected before and after treatment. Results The levels of low density lipid -eholesterol（LDL- C）,CRP ,IL- 6 and ox-LDL were markedly decreased in Xuezhiqing treatment group. There was no statistical significance between Xuezhiqing treatment group and rosuvastatin treatment group（P〉0.05）. Conclusion Xuezhiqing could effectivly reduce the levels of LDL- C,CRP, IL- 6 arid ox-LDL. It demonstrates that traditional Chinese medicine （TCM） method of clearing away heat,removing dampness,phlegm and turhidhy could prevent and treat atherosclerosis through amel iorating dyslipidemia and inhibiting inflammatory reaction.

关 键 词：血脂清 血脂异常 炎症因子 氧化低密度脂蛋白胆固醇 瑞舒伐他汀 

分 类 号：R259[医药卫生—中西医结合]