寄生原虫中糖基磷脂酰肌醇的研究进展  

Advanced on the study of GPI of Parasitic protozoa

作　　者：覃珊珊[1] 汪琦[1] 

机构地区：[1]广东药学院基础学院,广东广州510006

出　　处：《中国病原生物学杂志》2009年第10期787-789,796,共4页Journal of Pathogen Biology

摘　　要：糖基磷脂酰肌醇(GPI)锚作为翻译后修饰成分位于真核生物蛋白的C末端,将修饰后蛋白锚定在细胞膜的外侧小叶上。GPI结构复杂且GPI锚定蛋白在结构和功能上也相差甚远,其在许多生物学过程中都是不可缺少的。寄生原虫膜表面具有大量的GPI锚定蛋白以及GPI相关糖蛋白,能通过周期性的改变来逃避宿主的免疫反应。尽管某些GPI蛋白的特征已明确,但GPI锚的生物功能并没有在分子水平上得到解释。本文对GPI的结构、生物合成以及在原虫中的研究进展作了综述。The glycosylphosphatidylinositol （GPI） anchor is a posttranslational modification positioned at the C-terminus of many eukaryotic proteins that anchors the modified protein in the outer leaflet of the cell membrane. The structure of GPI anchor is complex and GPI-anehored proteins are structurally and functionally diverse and play vital roles in numerous biological processes. A large number of GPI-anchored protein and GPI-associated glycoprotein accumulated on the parasitic protozoan surface membrane that can escape host immune response through cyclical changes. Although several characters of GPI-protein have been identified, the biological functions of GPI anchor have yet to be elucidated at molecular lever. This review summarized the new research progress on the structure, biosynthesis of GPI and focused on the application of GPI in parasitic protozoan.

关 键 词：寄生原虫 糖基磷脂酰肌醇(GPI) 综述 

分 类 号：R382[医药卫生—医学寄生虫学]