β细胞复制的分子机制  

Molecular mechanism of β-cell replication

作　　者：洪靖[1] 杨文英[1] 

机构地区：[1]卫生部中日友好医院内分泌科,北京100029

出　　处：《中华内分泌代谢杂志》2009年第5期I0001-I0003,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：β细胞复制是维持β细胞量的重要形式。本文从Cyclin（细胞周期蛋白）、P13K（磷脂酰肌醇-3-激酶，phosphatidylinosilnl-3-kinase）、AKT（蛋白激酶B，protein kinase B）、GSK3（糖原合成酶激酶3，glycogen synthase kinase3）和Wnt信号转导通路，以及抑癌蛋白menin因子等角度讨论β细胞复制的分子机制。β-cell replication plays an important role in maintaining β-cell mass. Cyclins, phosphatidylinositol-3-kinase, protein kinase B, glycogen synthase kinase 3 and Wnt signal pathways are involved in beta cell replication,More recently, menin has been reported to regulate beta cell replication. In this review, the molecular mechanism of beta cell proliferation is highlighted.

关 键 词：β细胞量 β细胞复制 糖尿病 细胞周期蛋白 磷脂酰肌醇3激酶 蛋白激酶B 糖 原合成酶激酶3 

分 类 号：R587.1[医药卫生—内分泌] R735.7[医药卫生—内科学]