妊娠期高血压疾病妇女血清cTnI水平的测定  

Measurement of serum cTnI level in pregnant women with hypertensive disorder

作　　者：钱怡[1] 孙丽洲[1] 

机构地区：[1]南京医科大学第一附属医院妇产科,210029

出　　处：《江苏医药》2009年第11期1252-1254,共3页Jiangsu Medical Journal

基　　金：科技部国家"十一五"支撑计划(2007BA107A00)

摘　　要：目的探讨妊娠期高血压疾病孕妇血清心肌肌钙蛋白I(cTnI)水平变化。方法采用双抗体夹心ELISA法检测31例妊娠期高血压疾病患者(A组)(妊娠期高血压12例、子痫前期13例、妊娠合并慢性高血压1例、慢性高血压并发子痫前期5例),37例正常妊娠孕妇(B组)及32例正常非孕育龄妇女(C组)血清cTnI水平;从三组样本中各抽10例用Backman access化学发光免疫分析法(Backman法)重复检测。结果A、B、C三组ELISA法血清cTnI水平均为阴性。Backman法三组样本亦未见显著升高。结论妊娠期高血压疾病患者血清cTnI水平未见异常,此类患者心肌损伤及程度有待进一步研究。Objective To investigate the changes of serum cardiac troponin I （cTnI） level in pregnant women with hypertensive disorders. Methods The serum cTnI level was detected in 31 pregnant women with hypertensive disorder （group A）（gestational hypertension in 12 cases, preeclampsiae in 13 cases, pregnancy with chronic hypertension in 1 case, chronic hypertension complicating preeclampsia in 5 cases）, 37 normal pregnant controls （group B） and 32 unpregnant controls （group C） by ELISA technique. The serum cTnI was checked with Beckman access immunoassay in 10 samples from each group. Results Serum cTnI measured by ELISA was all negative in groups of A, B and C, which was not significantly elevated as well when measured by Beckman access immunoassay. Conclusion The abnormal increase in serum cTnI was not seen in this group, suggesting that the myocardial impairment in pregnant women with hypertensive disorders needs to be studied further.

关 键 词：妊娠期高血压疾病 肌钙蛋白I 心肌损伤 

分 类 号：R714[医药卫生—妇产科学]