耐甲氧西林葡萄球菌耐药性的监测与管理  

Mornitoring and management of antibiotic resistance in meticillin-resistant staphylococcus

作　　者：孔庆芳[1] 邵华[1] 程科萍[1] 叶南圆[1] 王长娴[1] 

机构地区：[1]东南大学附属中大医院感染管理科,南京210009

出　　处：《江苏医药》2009年第11期1275-1277,共3页Jiangsu Medical Journal

基　　金：江苏省卫生厅奥赛康基金(P200603)

摘　　要：目的探讨临床分离的葡萄球菌属的耐药性及其危险因素。方法用VITEK-2微生物分析系统对146例葡萄球菌检测阳性菌株进行鉴定及药物敏感试验。调查葡萄球菌检测阳性患者的基础疾病及危险因素等。结果葡萄球菌属对万古霉素、呋喃妥因、奎奴普汀-达福普汀、氯霉素和利奈唑烷敏感率较高(>80%)。耐甲氧西林葡萄球菌(MRS)对多种抗菌药物的耐药率均高于甲氧西林敏感葡萄球菌(MSS)。葡萄球菌感染患者的基础疾病主要为呼吸系统、神经系统、高血压、糖尿病、恶性肿瘤;危险因素主要为住院>15 d、静脉置管、低蛋白血症、年龄≥75岁。结论临床MRS耐药现象严峻,应重视多重耐药菌的监测和感染控制。Objective To investigate the mornitoring and management of antibiotic resistance in meticillin-resistant staphylococcus（MRS）. Methods Antibiotic susceptibility test was performed by biological assay system of VITEK-2. The messages of the patients＇ diseases and risk factors were questioned. Results Drug sensitive ratio to vancomycin, nitrofurantoin, quinupristin-dalfopristin, linezolid was over 80 %. The resistant rates to some antibacterials in MRS were higher than those in meticillin-sensitive staphylococcus（MS.S）. The basic diseases of the patients were those in respiratory apparatus and nervous system, hypertension, diabetes, and malignant tumor. The risk factors were hospitalization more than 15 days, vein puncture, hypoproteinemia and ages over 75 years old. Conclusion The multidrug resistance of MRS is very serious. Attention should be paid to mornitoring the multidrug resistance and controlling infection.

关 键 词：甲氧西林 葡萄球菌属 耐药性 

分 类 号：R978[医药卫生—药品]