原发性喉曲菌病6例临床分析  

Primary aspergillus laryngitis:report of six cases

作　　者：陈仁辉[1] 王豪[1] 姚卓华[1] 

机构地区：[1]汕头大学医学院第二附属医院耳鼻咽喉头颈外科,广东汕头515000

出　　处：《临床耳鼻咽喉头颈外科杂志》2009年第21期968-970,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:找寻喉真菌病的特征性临床表现。方法:回顾性分析6例喉曲菌病患者的临床诊治资料。结果:6例患者在服抗真菌药1周内声嘶缓解,白斑消失,1个月内症状完全消失。随访6个月～4年,至今仍未见复发。结论:声带弥漫性充血、肥厚、散在片状白斑是特征性的体征,病理是确诊喉曲菌病的主要手段。确诊后停用抗生素和激素,改用伊曲康唑口服2～4周即可治愈。Objective：To discuss the distinctive clinical manifestation of primary aspergillus laryngitis. Method：Six cases of primary aspergillus laryngitis in our department were reviewed,among which 3 cases were diabetes patients,and were laryngeal mucosal barrier impairment. 2 cases were smoking, 2 cases were over use of voice and 1 ease were gastro-pharyngeal reflux . Refractory hoarseness was the main clinical manifestation of all patients. The prophase treatment with antibiotics and glucocorticoid should breakdown the balance of flora and exacerbate the disease. Result：Stop using antibiotics and glucocorticoid and alter to oral administration of itraconazole in 2 to 4 weeks after final diagnosis can effectively cure the disease. No recurrence was found in 6 month to 4 years follow up. Conclusion：Diffuse hyperemia , pachynsis and scattered lamellar leukasmus of vocal cord were the characteristic physical findings of primary aspergillus laryngitis. Pathology is the major means to get the final diagnosis. Oral administration of itraconazole could be effective.

关 键 词：喉炎 曲菌病 

分 类 号：R763[医药卫生—耳鼻咽喉科]