2型糖尿病患者颈动脉硬化斑块形成的相关因素分析  

Factor Analysis of Carotid Angiosclerosis Plaque in Type 2 Diabetics

作　　者：徐礼五[1] 齐晓玲[1] 余洋[1] 王郭伟[1] 段成[1] 袁玲[1] 李晓蕾[1] 王江宁[1] 刘智[1] 

机构地区：[1]蚌埠医学院附属安徽淮南市第一人民医院内分泌肾病科,安徽省淮南市232007

出　　处：《中国动脉硬化杂志》2009年第8期695-697,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨2型糖尿病患者颈动脉硬化斑块形成的相关因素。方法123例2型糖尿病患者,根据颈动脉彩色超声结果分为颈动脉无硬化斑块组、颈动脉硬化斑块组,分别检测各组血清C反应蛋白、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血浆致动脉硬化指数、血尿酸、血肌酐,并记录年龄、糖尿病病程、体重指数、收缩压、舒张压、脉压差、吸烟史、高血压史、微血管并发症、颈动脉内膜厚度等指标,进行统计学处理。结果颈动脉硬化斑块组中年龄(P<0.01)、C反应蛋白(P<0.05)、颈动脉内膜厚度(P<0.01)以及微血管并发症发生率(P<0.05)均比颈动脉无硬化斑块组显著增高,差别均有统计学意义。Logistic回归分析显示,颈动脉内膜厚度与颈动脉硬化斑块形成独立相关(P<0.05)。结论2型糖尿病患者颈动脉硬化斑块形成与颈动脉内膜厚度、年龄、C反应蛋白等多因素有关,颈动脉内膜厚度增加是颈动脉硬化斑块形成的危险因素,颈动脉硬化斑块形成的同时微血管并发症的发生率增加。Aim To discuss the correlation factor of carotid angiosclerosis plaque in the patients with type 2 diabetes mellitus（T2DM）. Methods 123 cases of patients with T2DM,including non-carotid angiosclerosis plaque and carotid angiosclerosis plaque,were explored by color ultrasonoscope.The physical examinations included measurement of age,diabetes course,body mass index,blood pressure,smoking history,hypertension history,microangiopathy,carotid intima-media thickness,etc.Laboratory tests included serum C-reactive protein（CRP）,fasting blood glucose,total cholesterol,triglycerides,high density lipoprotein cholesterol,low density lipoprotein cholesterol,atherogenic index of plasma,uric acid and serum creatinine. Results The levels of serum CRP（P〈0.05）,age（P〈0.01）,carotid intima-media thickness（P〈0.01） and microangiopathy incidence（P〈0.05） in angiosclerosis plaque group were higher than those in non-angiosclerosis plaque group.Stepwise regression analysis of relative factors for carot...更多id angiosclerosis plaque showed that only the carotid intima-media thickness was significantly associated with the carotid angiosclerosis plaque（P〈0.05）. Conclusions Carotid angiosclerosis plaque may be related to carotid intima-media thickness,age and CRP in the patients with T2DM.Carotid intima-media thickness may be a risk factor of carotid angiosclerosis plaque.Micrangium complication incidence will be raised accompanying with the formation of carotid angiosclerosis plaque.

关 键 词：2型糖尿病 颈动脉硬化斑块 颈动脉内膜中层厚度 超声检查 C反应蛋白 危险因素 

分 类 号：R5[医药卫生—内科学]