急性运动后健康人循环内皮祖细胞的动态变化及其与NO水平的关系  

Dynamic Changes of Circulating Endothelial Progenitor Cells and Its Correlation with Plasma NO Level in Healthy Subjects in Response to Acute Exercise

作　　者：杨震[1] 李德昶[2] 夏文豪[1] 刘志豪[3] 廖燕红[1] 吴芳[1] 苏晨[1] 王洁梅[1] 陈龙[1] 陶军[1] 

机构地区：[1]中山大学附属第一医院高血压血管病科,广东广州510080 [2]广东省信宜市人民医院心内科,广东信宜525300 [3]中山大学附属第一医院心内科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2009年第5期501-506,共6页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金项目(30770895;U0732002;30800215);广东省自然科学基金博士启动项目(8451008901000793);广州市科技计划项目(2007Z3-E0241)

摘　　要：【目的】探讨急性运动后健康成人循环内皮祖细胞(EPC)数量和功能的动态变化及其与一氧化氮(NO)水平的关系。【方法】选择8例男性健康志愿者,动态观察急性运动前以及运动后30min、3h、6h、12h和24h循环内皮祖细胞数量和功能,同时检测运动前后血浆NO水平的变化。【结果】急性运动后30min,健康志愿者循环内皮祖细胞的数量和功能上升至最高峰,运动后3h已开始逐渐下降,运动后24h回落至正常水平,这种变化与血浆NO水平的动态变化趋势基本相似。血浆NO水平与循环内皮祖细胞数量和功能呈直线相关回归关系。【结论】急性运动上调健康成人循环内皮祖细胞数量和功能的维持时间较为短暂,可能与血浆NO水平的下降有关。提示需要长期运动锻炼以维持对健康成人循环内皮祖细胞数量和功能的上调作用。【Objective】 The study was to investigate the dynamic changes of the number and activity of circulating endothelial progenitor cells （EPC） in healthy subjects in response to acute exercise. 【Methods】 The number and activity of circulating EPC in 8 cases of male healthy subjects before and 30 minutes, 3 h,6 h,12 h,and 24 h after exercise were observed. The levels of NO in plasma at the above different time point were measured. 【Results】 At about 30 minutes after acute exercise, the number and activity of circulating EPC reached the peak, decreased at 3 h after acute exercise, and returned to the baseline at 24 h after acute exercise, which was similar to the changes of plasma NO levels. There was linear regression correlation between plasma NO levels and the number or activity of circulating EPC. 【Conclusion】 The up-regulated number and activity of circulating EPC by acute exercise sustained transient, which may be related to the changes of plasma NO levels. It indicated that long-term physical training is essential for sustaining the up-regulation of number and activity of circulating EPC.

关 键 词：运动 内皮祖细胞 一氧化氮 内皮功能 心血管疾病 

分 类 号：R541.4[医药卫生—心血管疾病]