老年慢性心力衰竭患者血浆TNF-α和MMP-9浓度检测的意义  

Clinical significant of the TNF-α and MMP-9 concentration in elderly patients with CHF

作　　者：胡生明[1] 张兴旺[1] 吕文涛[1] 谢萍[2] 居军[1] 

机构地区：[1]甘肃省人民医院检验中心,甘肃兰州730000 [2]甘肃省人民医院心内科,甘肃兰州730000

出　　处：《第四军医大学学报》2009年第21期2376-2378,共3页Journal of the Fourth Military Medical University

摘　　要：目的:探讨老年慢性心力衰竭(CHF)患者血浆肿瘤坏死因子-α(TNF-α)和基质金属蛋白酶-9(MMP-9)浓度检测的意义.方法:采用ELISA方法测定100例老年心力衰竭患者(CHF组)和50例健康者(对照组)的血浆TNF-α和MMP-9浓度,经胸超声心动图检查,测出左心室参数.结果:老年CHF组血浆TNF-α和MMP-9浓度均高于对照组,且随着心力衰竭程度的加重而显著增加(P<0.05);老年CHF组血浆TNF-α和MMP-9浓度分别与左心室舒张末内径呈正相关(P<0.05),而与左心室射血分数及左心室短轴缩短率呈负相关(P<0.05),并且TNF-α和MMP-9浓度之间呈显著正相关(P<0.05).结论:老年CHF血浆TNF-α和MMP-9浓度水平密切相关,其浓度的检测有助于判断CHF病情的严重程度.AIM：To investigate the clinical significant of Tumor necrosis factor-α （TNF-α） and matrix metalloproteinase-9 （MMP-9） concentration in elderly patients with chronic heart failure （CHF）. METHODS：100 patients with CHF and 50 healthy controls were examined by echocardiography,and their TNF-α and MMP-9 concentration were detected by ELISA. RESULTS：The plasma level of TNF-α and （MMP-9 of CHF group were higher than those of the control group,and increased with the severity of heart failure. The level of TNF-αand MMP-9 were positively correlated with the left ventricular and diastolic diameter （LVEDD）, and negatively correlated with the left ventricular ejection fraction （LVEF） and left ventricular fraction shorter （LVFS）. TNF-α levels were positively related to MMP-9 levels （all P 〈 0.01 ）. CONCLUSION： Plasma levels of TNF-α are consistent with the increased level of MMP-9 in elderly patients with CHF. It suggest that TNF-α and MMP-9 play an important role in the development of heart failure . The measurement of TNF- α and MMP-9 will be helpful for the diagnosis prognosticate and predict the development of CHF.

关 键 词：老年 心力衰竭 基质金属蛋白酶-9 肿瘤坏死因子-Α 

分 类 号：R541.6[医药卫生—心血管疾病]