脂联素与高血压病患者心肌纤维化及血管内皮功能的相关性研究  

Correlation between adiponectin and myocardial fibrosis,vascular endothelial function in hypertensives

作　　者：金爱萍[1] 

机构地区：[1]西安交通大学第二医院老年病科,陕西西安710004

出　　处：《第四军医大学学报》2009年第21期2382-2384,共3页Journal of the Fourth Military Medical University

摘　　要：目的:观察脂联素与高血压病患者心肌纤维化及血管内皮功能的相关性,探讨脂联素对高血压心肌纤维化的影响及作用机制.方法:测定80例初发高血压病患者(高血压组)和80例健康者(对照组)的血清脂联素、血浆内皮素-1(ET-1)、血清Ⅰ型前胶原(PCⅠ)、Ⅲ型前胶原(PCⅢ)、血清一氧化氮(NO)、肱动脉血流介导的血管内皮依赖性舒张功能(FMD)等指标.结果:高血压组患者的血清PCⅠ,PCⅢ、血浆ET-1和收缩压显著高于对照组(P<0.05),血清脂联素、NO和FMD显著低于对照组(P<0.05).高血压病患者的血清脂联素与FMD(r=0.483)和NO(r=0.417)呈显著正相关;与血清PCⅢ(r=0.601),PCⅠ(r=0.552),ET-1(r=0.429)和收缩压(r=0.321)呈显著负相关.结论:脂联素可通过增加NO,减少ET-1的释放而改善血管内皮功能,抑制高血压心肌纤维化过程.AIM：To investigate the correlation between adiponectin and myocardial fibrosis,vascular endothelial function and evaluate function and mechanism of adiponectin on myocardial fibrosis in hypertension. METHODS：Serum adiponectin,plasma endothelin-1 （ET-1）,procollagen typeⅠ（PCⅠ）,procollagen type Ⅲ （PCⅢ）,serum nitric oxide （NO） and flow-mediated dilation （FMD） were measured in eighty newly diagnosed hypertensives （hypertensive group） and eighty healthy persons （control group）. RESULTS：PCⅠ,PCⅢ,plasma ET-1 and systolic pressure were significantly higher than in control group （P 〈 0.05 ）, while serum adiponectin, NO and FMD were significantly lower than in control group （ P 〈 0.05 ）. Serum adiponectin levels were positively correlated with FMD （ r = 0. 483 ） and NO （ r = 0.417）, while negatively correlated with PC Ill （ r = 0. 601 ）, PC [ （r=0.552）,ET-1 （r=0.429） and systolic pressure （r= 0.321 ）. CONCLUSION： Adiponectin may improve vascular endothelial function and inhibit myocardial fibrosis in hypertension via increasing NO and reducing ET-1.

关 键 词：脂联素 高血压 心肌纤维化 血管内皮功能 

分 类 号：R544.1[医药卫生—心血管疾病]