肺炎合并心力衰竭患儿血清心型脂肪酸结合蛋白的水平变化及意义  

Serum levels of fatty acid-binding protein in children with pneumonia complicated by acute congestive heart failure

作　　者：高晓敏[1] 张西嫔[1] 白秀生[1] 刘虹[1] 

机构地区：[1]陕西省人民医院儿科,陕西西安710068

出　　处：《第四军医大学学报》2009年第21期2385-2386,共2页Journal of the Fourth Military Medical University

摘　　要：目的:通过观察肺炎合并心力衰竭(HF)患儿血清心型脂肪酸结合蛋白(H-FABP)的水平变化,探讨其在肺炎合并心力衰竭患儿中的临床价值.方法:选择肺炎合并心力衰竭患儿42例为研究对象,40例单纯肺炎组和35例健康儿童为对照组.在不同时间段进行心型脂肪酸结合蛋白(H-FABP)及常规检测项目肌酸激酸同功酶(CK-MB)和肌钙蛋白Ⅰ(cTnI)的检测.结果:42例HF患儿的CK-MB及cTnI在HF起病后6～8h开始升高,24h达到高峰;H-FABP在HF起病后6～8h达到峰值,24h后迅速下降.HF患儿三项指标高峰值与单纯肺炎组和健康儿童对照组比较差异均有统计学意义(P<0.01).结论:CK-MB及cTnI作为早期诊断指标欠佳,H-FABP可作为HF早期诊断的最佳指标.AIM：To investigate pneumonia with heart failure （HF） of serum heart-type fatty acid binding egg white No. （H-FABP） level changes of pneumonia with heart failure in children with the clinical value. METHODS：Children with pneumonia complicated by heart failure 42 cases studied,40 cases of simple pneumonia and 35 cases of healthy children as control group. Carried out at different time heart-type fatty acid binding protein （H-FABP） and conventional test items creatine kinase isoenzyme （CK-MB） and troponin Ⅰ detection.RESULTS： Forty-two cases of HF in children with the CK-MB and CTnI at onset HF after 6 - 8 h start rising, 24 h peaked; H-FABP at onset HF after 6 - 8 h peak, 24 h after the rapidly declining. Three indicators of the peak value with simple pneumonia and two healthy children control group differences were statistically significant, simple pneumonia and healthy children two groups revealed no statistically significant difference. CONCLUSION： CK-MB and CTnI as poor indicators of early diagnosis, HFABP the early diagnosis of I-IF can be used as the best indicator.

关 键 词：肺炎 心力衰竭 心型脂肪酸结合蛋白 肌钙蛋白Ⅰ 肌酸激酸同功酶 

分 类 号：R563.1[医药卫生—呼吸系统] R541.6[医药卫生—内科学]