朱砂的药理及毒理机制研究进展  

Progresses on mechanisms of pharmacological and toxicological effects of cinnabar

作　　者：周昕睿[1] 王旗[2] 杨晓达[1] 

机构地区：[1]北京大学药学院化学生物学系,北京100191 [2]北京大学公共卫生学院毒理学系,北京100191

出　　处：《中国中药杂志》2009年第22期2843-2847,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30672653)

摘　　要：朱砂及含朱砂的中成药疗效确切,其有毒无毒的问题自古争论至今仍无定论。早期文献综述较多报道朱砂药效或毒性的作用结果,少有关于机制方面的研究。近年来,一些研究者开始探讨朱砂药理及毒理作用机制,以评价朱砂的安全性及其在中药复方中的药效学必要性。本文对2000年以来国内外朱砂作用机制的研究进行评述。Cinnabar has been an important traditional Chinese medicine as a sedative and soporific agent for more than 2000 years. It is a naturally occurring mercuric sulfide and containing more than 96% mercuric sulfide （HgS）. There are about 10% -30% Chinese patent medicines containing cinnabar according to the Pharmacopoeia of China （2005）. It＇s hard tO deny that cinnabar has therapeutic effect in clinic practice. However, cinnabar＇s extraordinary high containing mercury makes people hesitate to use. Furthermore, the abuse of cinnabar, which caused intoxication cases, has been reported occasionally. The safety and toxicity of cinnabar has been debated for centuries. The exact mechanism of cinnabar is still largely unknown. The present review focused on researches about cinnabar＇s mechanisms of pharmacological and toxicological effects since 2000.

关 键 词：朱砂 药理机制 毒理机制 

分 类 号：R285.5[医药卫生—中药学]