仙灵骨葆胶囊治疗围绝经期综合征患者的临床研究  

Clinic research on Xianling Gubao capsules for treatment of manopause syndrome

作　　者：楼红英[1] 黄东[1] 方素华[1] 赵小峰[1] 黄琼晓[1] 王敏珍[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院妇产科,浙江杭州310016

出　　处：《中国中药杂志》2009年第22期2950-2952,共3页China Journal of Chinese Materia Medica

基　　金：浙江省中医药科技计划项目(491030-W50703)

摘　　要：目的:观察仙灵骨葆胶囊对围绝经期综合征患者性激素的影响及改善临床症状的疗效。方法:经临床诊断有围绝经期综合征的妇女,采用随机数字表法将纳入的病例随机分为治疗组及对照组,其中完成随访的治疗组80例,对照组30例。治疗组服用仙灵骨葆胶囊,对照组服用外观一致的模拟淀粉胶囊,疗程8周。观察患者治疗前后Kupperm an评分,雌二醇(E2)值及子宫内膜厚度。结果:治疗组治疗后Kupperm an评分值明显改善并优于对照组(P<0.01);血清E2水平明显升高,且优于对照组(P<0.05);治疗前后子宫内膜厚度比较,无显著差异。结论:仙灵骨葆胶囊能提高围绝经期综合征患者血清E2水平,显著改善围绝经期综合征患者临床症状,不增加子宫内膜增生的风险。Objective： To observe the clinical effectsr and the serous estradiol change of patients with menopause syndrome using Xianling Gubao capsules for treatment. Method： 110 patients with manopause syndrome who were diagnosized by clinic index were recruited for the Study. They Were divided into two groups randomly. The treatment group were dealed with Xianling Gubao capsules and the control group with placebo of starch capsules for 8 weeks. The menopausal Kupperman index was used to assess change in menopausal symptoms before and after treatment. At the Same time, serous estradiol and the thickness of uterine endometrium was evaluated. Result： The Kupperman index were improved apparently in treatment group after treatment （P 〈 0.01 ）. The serous estradiol level of treatment group was increased apparently after treatment （P 〈 0. 05 ）. However, There were no statistical deference in the thickness of uterine endometrium in tbe treatment and the control group before and after treatment. Conclusion： The treatment using Xianling Gubao capsules for patients with menopause syndrome could improve the clinic symptoms, increase the serous estradiol level, but do not increase the risk of endometrial hyperplasia.

关 键 词：仙灵骨葆胶囊 围绝经期综合征 雌二醇(E2) 

分 类 号：R271.9[医药卫生—中西医结合]