Pericryptal Fibroblast Sheath in Intestinal Metaplasia,Dysplasia and Carcinoma of the Stomach  

作　　者：Lu-ying Liu Yu Sun Zhong-wu Li Guoshuang Feng Wei-cheng You Ji-you Li 

机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） [2]Department of Pathology [3]Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital ＆ Institute, Beijing 100142, China [4]Department of Pathology, Binzhou Medical College, Binzhou, China

出　　处：《Chinese Journal of Cancer Research》2009年第4期290-294,共5页中国癌症研究（英文版）

基　　金：supported in part by the grants from Beijing Municipal Science & Technology commission NOVA program (No.2005B-44);the National"863"High-Tech Res & Dev program of China(No.2006AA02A402);the Major State Basic Research Program of china(No.2004CB518702)

摘　　要：Objective： To investigate the existence of pericryptal fibroblasts sheath （PCFS） in normal gastric mucosa, intestinal metaplasia （IM）, indefinite for dysplasia （I-Dys）, low grade dysplasia （L-Dys）, high grade dysplasia （H-Dys） and gastric cancer （GC）, and its association with gastric carcinogenesis. Methods： In this study, we examined the existence of PCFS in normal gastric mucosa （N=10）, IM （N=26）, I-Dys （N=16）, L-Dys （N=13）, H-Dys （N=21） and GC （N=145） using immunohistochemical staining for two smooth muscle markers, alpha smooth muscle actin（α-SMA） and high molecular weight caldesmon （h-CD）. The significance of PCFS was discussed, especially in association with gastric carcinogenesis. Results： The PCFS was recognized in 65.4%（17/26） of IM, 62.5%（10/16） of I-Dys and 23.1% （3/13） of L-Dys respectively. No PCFS was detected in H-Dys and GC. The PCFS was gradually reduced in IM, Dys and GC in sequence （P〈0.0001）. Conclusion： The PCFS is associated with the differentiation of epithelium and involved in gastric carcinogenesis via epithelial-mesenchymal interaction.Objective： To investigate the existence of pericryptal fibroblasts sheath （PCFS） in normal gastric mucosa, intestinal metaplasia （IM）, indefinite for dysplasia （I-Dys）, low grade dysplasia （L-Dys）, high grade dysplasia （H-Dys） and gastric cancer （GC）, and its association with gastric carcinogenesis. Methods： In this study, we examined the existence of PCFS in normal gastric mucosa （N=10）, IM （N=26）, I-Dys （N=16）, L-Dys （N=13）, H-Dys （N=21） and GC （N=145） using immunohistochemical staining for two smooth muscle markers, alpha smooth muscle actin（α-SMA） and high molecular weight caldesmon （h-CD）. The significance of PCFS was discussed, especially in association with gastric carcinogenesis. Results： The PCFS was recognized in 65.4%（17/26） of IM, 62.5%（10/16） of I-Dys and 23.1% （3/13） of L-Dys respectively. No PCFS was detected in H-Dys and GC. The PCFS was gradually reduced in IM, Dys and GC in sequence （P〈0.0001）. Conclusion： The PCFS is associated with the differentiation of epithelium and involved in gastric carcinogenesis via epithelial-mesenchymal interaction.

关 键 词：Pericryptal fibroblasts sheath （PCFS） Gastric cancer （GC） CARCINOGENESIS Intestinal metaplasia （IM） DYSPLASIA 

分 类 号：Q421[生物学—神经生物学] Q516[生物学—生理学]