比索洛尔对原发性高血压患者左室肥厚逆转效应  

Effect of bisoprolol on left ventricular hypertrophy

作　　者：张博[1] 

机构地区：[1]锦州市中心医院心内科,辽宁锦州121000

出　　处：《心脏杂志》2009年第6期838-840,共3页Chinese Heart Journal

摘　　要：目的:探讨比索洛尔对原发性高血压病左室肥厚的逆转作用。方法:选择40例轻中度高血压病伴左室肥厚患者,口服比索洛尔24周,测量服药前后血压变化;通过超声心动图测量患者服药前后舒张末期室间隔厚度(LVST),舒张末期左室后壁厚度(LVPWT),左室舒张末内径(LVEDD),左心室质量指数(LVMI)。检测服药前后血清中Ⅲ型前胶原(PCⅢ),胰岛素样生长因子(IGF-I),肿瘤坏死因子-α(TNF-α)的变化。结果:治疗后上述指标较治疗前明显减低,差异有显著性(P<0.01)。结论:比索洛尔能有效降低血压并逆转左室肥厚,其机制可能与抑制IGF-I、TNF-α的生成有关。AIM： To observe the effect of bisoprolol on left ventricular hypertrophy. METHODS： Forty patients with essential hypertension and left ventricular hypertrophy （LVH） were treated with bisoprolol （2.5-10 mg/day） for 24 weeks. Blood pressure, left ventricle diastolic dimension （LVEDD）, interventricular septum thickness （LVST）, left ventricle mass index （LVMI）, left ventricle posterior wall thickness （LVPWT）, procollagen type III （PCIII）, insulin-like growth factor-I （IGF-I）, and tumor necrosis factor-α （TNF-α） were measured before and after treatment. RESULTS： After bisoprolol treatment, blood pressure and LVMI, LVPWT, LVST and LVEDD levels significantly decreased （P〈0.01）. In addition, PCIII, IGF-I and TNF-α levels also significantly decreased （P〈0.01）. CONCLUSION： Bisoprolol lowers hypertension and reverses LVH. The protective mechanism may be related to its ability to reduce IGF-I and TNF-α.

关 键 词：高血压 原发性 比索洛尔 左室重构 

分 类 号：R544.1[医药卫生—心血管疾病]