冠心病急性心肌梗死并发糖尿病患者血清PPARγ的变化  

Relationship between PPARγ and coronary heart disease and acute myocardial infarction in diabetes

作　　者：张瑞英[1] 莫成利[1] 富路[1] 康晓宁[1] 

机构地区：[1]哈尔滨医科大学附属一院心内科,黑龙江哈尔滨150001

出　　处：《心脏杂志》2009年第6期848-850,共3页Chinese Heart Journal

基　　金：哈尔滨市学科后备带头人基金资助(2005AFXXJ047);省攻关课题项目资助(GC05C40304)

摘　　要：目的:探讨血清过氧化物酶体增殖物激活受体γ(PPARγ)与冠心病、Ⅱ型糖尿病并发急性心肌梗死(AMI)的关系。方法:经冠脉造影证实的冠心病患者,分为稳定型心绞痛(SAP)组、不稳定型心绞痛(UAP)组、AMI组、Ⅱ型糖尿病并发AMI(AD)组,经冠脉造影证实冠脉正常者为对照组。入院后抽取静脉血,测定PPARγ、血脂、空腹血糖(FPG)等。结果:各组间比较PPARγ水平,SAP组与对照组无显著差异,UAP组、AMI组、DA组与对照组比较,PPARγ水平显著下降(P<0.01)。结论:与单纯AMI组相比,AD组PPARγ降低更加显著。AIM： To study the relationship between serum PPARγ level and coronary heart disease （CHD） and acute myocardial infarction （AMI） in type II diabetes mellitus （T2DM）. METHODS： Patients diagnosed as having CHD by coronary artery opacification were divided into four groups： stable angina pectoris group （SAP）, unstable angina pectoris group （UAP）, AMI group, and AMI/T2DM group （AD）. Subjects relieved from CHD by coronary artery opacification were selected as control group. Venous blood of all study subjects was taken to determine PPARγ, blood lipids and fasting blood glucose. RESULTS： No significant difference was found in PPARγ level between SAP group and control group. PPARγ levels in SAP group, UA group, AMI group and AD group were significantly lower than in control group （P〈0.01）. CONCLUSION： PPARγ level in patients with AMI complicated by T2DM is obviously lower than in patients with AMI.

关 键 词：过氧化物酶体增殖物激活受体Γ 冠状动脉疾病 糖尿病 Ⅱ型 

分 类 号：R541.4[医药卫生—心血管疾病]