阿莫西林钠-酒石酸泰乐菌素复方药物治疗猪链球菌病的研究  

Study on the amoxillin-tylosin tartrate compound against Streptococcos suis in mice

作　　者：王敏[1] 徐刚[1] 刘洋[1] 陈俭清[1] 李艳华[1] 

机构地区：[1]东北农业大学动物医学学院,哈尔滨150030

出　　处：《东北农业大学学报》2009年第11期91-94,共4页Journal of Northeast Agricultural University

基　　金：国家科技支撑项目(2008BADB4B04-03);哈尔滨市科技攻关项目(2007AA6CN033)

摘　　要：为研究阿莫西林钠-酒石酸泰复方药物乐菌素治疗猪链球菌病的药效学,选用60只15g左右的昆明鼠,以多重耐药的临床分离猪链球菌为病原,以腹腔注射为感染途径,对猪链球菌的病理模型进行了复制,按照Reed-Munch法计算LD50为9.61×108cfu·mL-1。在此基础上,选用80只昆明鼠,接种LD50菌液,分别口服阿莫西林钠,酒石酸泰乐菌素及阿莫西林钠-酒石酸泰乐菌素复方药物。结果表明,阿莫西林钠-酒石酸泰乐菌素复方药物组的作用效果明显优于单药组,小鼠存活率为80%,阿莫西林钠组的小鼠存活率为70%,酒石酸泰乐菌素组为60%。To evaluate the pharmacodynamics of amoxillin-tylosintartrate against Streptococcus suis in Kunming mice. Kunming mice were infected by intraperitoneal injection with 1 mL of Streptococcus suis isolated. LD50 was 9.61 ×10^8 cfu· mL^-1 by Reed-Muench method. The mice were given by amoxillin, tylosin tartrate and amoxillin-tylosin tartrate compound respectively. The results showed that amoxillin-tylosintartrate was better than amoxilin, the survival rate was 80%.

关 键 词：阿莫西林钠 阿莫西林钠-酒石酸泰乐菌素复方药物 猪链球菌病 昆明鼠 药效学 

分 类 号：S852[农业科学—基础兽医学] S829[农业科学—兽医学]