葫芦巴粗提物对链脲佐霉素诱导的糖尿病大鼠骨密度的作用  

Effect of Crude Extract of Trigonella on Bone Mineral Density in Rats with Streptozotocin-induced Diabetes Mellitus

作　　者：卢芙蓉[1] 秦铀[2] 熊鹏程[1] 沈霖[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合科 [2]华中科技大学同济医学院附属协和医院血液病研究所

出　　处：《中国中医骨伤科杂志》2009年第11期17-18,共2页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：湖北省卫生厅资助课题;编号:鄂卫发2006(63)

摘　　要：目的:观察葫芦巴总皂苷(TFGs)对链脲佐霉素(STZ)诱导的糖尿病大鼠骨密度(BMD)及骨组织计量学的影响。方法:采用STZ腹腔注射复制糖尿病模型,采用TFGs治疗后,观察各组大鼠骨密度和骨组织计量学指标的变化。结果:与对照组大鼠相比,模型组大鼠全身及股骨BMD和平均骨小梁厚度(MTPT)明显降低,而平均骨小梁间距(MTPS)明显增高;与模型组大鼠相比,治疗组大鼠全身及股骨BMD和MTPT均明显增高,而MTPS明显降低。结论:TFGs可能具有改善糖尿病相关骨质疏松的作用。Objective：To explore the influence of trigonella foenum graecum L total saponin（TFGs） on bone mineral density（BMD） and bone histomorphometric profile in streptozotocin（STZ）-induced diabetic rats.Methods：Peritoneal injection of STZ was performed to establish diabetic models in rats.After the treatment with TFGs,BMD and bone histomorphometric profile were measured in all groups.Results：Compared with control group,whole-body BMD and femoral BMD as well as mean trabecular plate thickness（MTPT） in model group were significantly lower while mean trabecular plate separation （MTPS） was notably higher. After the treatment with TFGs, whole-body BMD, femoral BMD and MTPT were remarkably elevated and MTPS decreased in treatment group than those in model group. Conclusion：TFGs might have the function of ameliorating diabetes related osteoporosis.

关 键 词：葫芦巴 糖尿病 链脲佐霉素 骨密度 骨质疏松 

分 类 号：R681[医药卫生—骨科学]