聚乙二醇基氯硝柳胺衍生物体外抑制钉螺乙酰胆碱酯酶活性的研究  

Inhibitory effects of niclosamide derivatives containing polyethylene glycol groups on acetylcholinesterase activity of Oncomelania snail in vitro

作　　者：郭维[1] 吴勇权[1] 许丽荣[1] 郑绿茵[1] 范小林[1] 

机构地区：[1]赣南师范学院江西省有机药物化学重点实验室,江西赣州341000

出　　处：《化学试剂》2009年第11期907-909,共3页Chemical Reagents

基　　金：国家科技支撑计划重点课题(2009BAI78B012009BAI78B02);江西省科技厅重大招标项目(2006);江西省自然科学基金资助项目(2007GQH0366)

摘　　要：为研究聚乙二醇基氯硝柳胺衍生物体外抑制钉螺乙酰胆碱酯酶的活性,测定了氯硝柳胺衍生物抑制钉螺乙酰胆碱酯酶的半数抑制浓度IC50。结果表明:随着氯硝柳胺衍生物浓度的增加,对乙酰胆碱酯酶活性的抑制作用逐渐增强;随着聚乙二醇基链长的增加,药物对乙酰胆碱酯酶抑制活性依次减弱。The concentrations causing 50% inhibition （IC50） of acetylcholinesterase （ACHE） activity by niclosamide derivatives containing polyethylene glycol groups were determined in order to study the effects of niclosamide derivatives on AChE of oncomelania snail in vitro. Test results showed that an increasing drugs concentration would lead to the enhancement of inhibitory effects. With an increasing chain length of polyethylene glycol group linked on niclosamide, the inhibitory effects weakened.

关 键 词：氯硝柳胺衍生物 聚乙二醇基 钉螺 乙酰胆碱酯酶 

分 类 号：R383.24[医药卫生—医学寄生虫学]