α,β-不饱和酮衍生物的合成  

Synthesis of α,β-unsaturated carbonyl derivatives

作　　者：李红彩[1] 杨新美[1] 王朋[1] 赵桂森[1] 

机构地区：[1]山东大学药学院,山东济南250012

出　　处：《化学试剂》2009年第11期933-935,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(20672069);山东省自然科学基金资助项目(Y2007C060)

摘　　要：以2,3-二取代-4-(1-氧代-丙基)苯氧基乙酸、多聚甲醛、二甲胺盐酸盐为起始原料,在冰乙酸的催化下经曼尼西反应得到2,3-二取代-4-(2-二甲胺基亚甲基-1-氧代-丙基)苯氧基乙酸盐酸盐,然后经水解反应得到了目标化合物。该方法操作简便,收率较高,有较强的实验室应用价值。The target compounds were prepared in two steps. The reaction of starting materials [2,3-disubstituted-4-（1-oxopropyl） phenoxy]-acetic acid with paraformaldehyde and dimethylamine hydrochloride in the presence of glacial acetic acid gave the Mannich compounds, which were then converted to α,β-unsaturated carbonyl derivatives under alkaline condition via the elimination reaction. This method could be realized easily with good yield.

关 键 词：Α Β-不饱和酮 曼尼西反应 合成 

分 类 号：O625.42[理学—有机化学]