超选择造影与实时乳胶灌注在兔脑动脉系统研究应用  

A combined study of cerebral artery system through super - selective angiography and real - time - colored latex perfusion in rabbits

作　　者：张桂运[1] 陈左权[1] 凌锋[2] 海舰[1] 李玉健[1] 顾斌贤[1] 吴春红[1] 俞丽敏[1] 

机构地区：[1]同济大学附属同济医院神经外科,上海200065 [2]首都医科大学附属宣武医院神经外科

出　　处：《中华神经外科杂志》2009年第10期950-953,共4页Chinese Journal of Neurosurgery

基　　金：基金项目：国家自然科学基金资助（30872678）

摘　　要：目的研究兔脑动脉系统的特点，为建立兔脑血管疾病模型奠定基础。方法应用微导管技术对新西兰大白兔进行超选择性脑血管造影并进行血管三维重建，造影完毕后在活体上透视下经微导管进行染色乳胶实时灌注。结果主动脉弓上血管及颅内前后循环系统显影清楚；乳胶灌注后清晰显示颅底动脉环、大脑前动脉、大脑巾动脉、大脑后动脉及其皮层分枝，后分水岭区阻力血管显示清楚。结论超选择性脑血管造影有利于更好地显示兔脑前后动脉系统，染色乳胶灌注可以提供更多细节信息，有利于对脑血管造影的进一步认证。二者的结合研究有利于对兔脑循环形态学改变的观察。Objective To study the character of cerebral artery system in rabbits and to found the base for establishing cerebrovaseular disease models of rabbits. Methods Microcatheter - technique was used to perform super - selective cerebral angiography in New Zealand rabbits, after which three dimensional vascular reconstructions were adopted. At the end of angiography, the live rabbits, through mierocatheter, were real time peffused with colored latex mixed with contrast medium under fluoroscopy for visualization of their cerebrovascular anatomy. Results The arteries above aortic arch and the arterial system in anterior and posterior eirculation were clearly visualized. After latex peffusion, the arterial circle of skull base, anterior cerebral arteries, middle cerebral arteries, posterior cerebral arteries and their subpial branches were clearly displayed as well asthe resistanee vessels in posterior watershed. Conclusions Super - selective cerebra/angiography was helpful to better display the anterior and posterior circulation in rabbits, and the colored latex peffusion could provide more details about the microcirculation especially in the posterior watershed. The outcome of colored latex peffusion could be used as an authentication to angiography. With the combination of super - selective angiography and colored latex peffusion, it was easy to find the morphological changes of cerebral arterial circulation in rabbits.

关 键 词：兔 脑血管 超选择造影 乳胶灌注 

分 类 号：R686[医药卫生—骨科学]