抗苗勒氏管激素在多囊卵巢综合征中的诊断价值初探  

The Diagnostic Value of Serum Anti-Müllerian Hormone (AMH) Measurement in PCOS

作　　者：李琳[1] 翁梅英[1] 陈晓莉[1] 陈亚肖[1] 钟俊敏[1] 杨冬梓[1] 

机构地区：[1]中山大学附属第二医院,广东广州510120

出　　处：《实用妇产科杂志》2009年第11期658-661,共4页Journal of Practical Obstetrics and Gynecology

基　　金："十一五"国家科技支撑计划项目(项目编号:2007BA104B00);广东省医学科研基金项目(项目编号:B2009069)

摘　　要：目的:研究多囊卵巢综合征(PCOS)患者的血清抗苗勒氏管激素(AMH)水平,并初步探讨其在PCOS中的诊断价值。方法:收集2006年6月至12月在我院妇产科就诊的47例PCOS患者(研究组)和年龄匹配的40例健康女性(对照组),应用酶联免疫吸附(ELISA)法检测血清AMH水平。结果:研究组的血清AMH水平明显高于对照组(9.85±4.93ng/mlvs7.13±3.02ng/ml,P=0.002)。血清AMH的曲线下面积在总体人群为0.664(P=0.008),以血清AMH8ng/ml为相对最佳的诊断界值,敏感度为61.7%,特异度为70.0%。结论:PCOS患者的血清AMH水平明显增高,血清AMH测定对于PCOS的诊断效能较低。Objective：To detect the serum anti-Mullerian hormone （AMH） level of patients with polycystic ovary syndrome （PCOS）, and to explore the diagnostic value of serum AMH measurement in PCOS. Methods ： 47 patients with PCOS and 40 healthy females ware enrolled from June 2006 to December 2006 in the Second Affiliated Hospital of Sun Yat-sen University. Serum AMH levels ware measured by enzyme linked immunosorbent assay （ ELISA）. Results ：The mean serum AMH level in PCOS group was significantly higher than control group （9.85±4.93 ng/ml vs 7.13± 3.02ng/ml, P= 0.002）, which is similar in adult PCOS patients and controls （10.64±5.47 ng/ml vs 7.01 ± 2.43 ng/ml, P = 0.005）. No difference was found in serum AMH of adolescent PCOS patients and controls （8.95 ± 4.18 ng/ml vs 7.26± 3.58 ng/ml, P= 0.168）. The areas under the ROC curve for AMH in all PCOS population, adults and adolessents ware 0.664 （P=0.008）, 0.714 （P=0.015）, and 0.614 （P=0.208）, respectively. The best compromise between specificity （70.0%） and sensitivity （61.7%） was obtained with a cut-off value of 8 ng/ml. Conclusions ：Serum AMH level was elevated in patients with PCOS. Serum AMH measurement offers a poor sensitivity of 61.7% and a specificity of 70% with a cut off value at 8 ng/ml, suggesting the diagnostic value of AMH was limited.

关 键 词：多囊卵巢综合征 抗苗勒氏管激素 诊断价值 

分 类 号：R711.5[医药卫生—妇产科学]