从抗组胺药的作用机制谈其治疗慢性荨麻疹的应用策略  

The clinical Application Strategy of Antihistamines for Chronic Urticaria Based on the Advanced Pharmacological Mechanisms

作　　者：郝飞[1] 钟华[1] 宋志强[1] 

机构地区：[1]第三军医大学西南医院皮肤科,重庆400038

出　　处：《中国皮肤性病学杂志》2009年第11期763-764,共2页The Chinese Journal of Dermatovenereology

摘　　要：抗组胺药物通常通过拮抗H1受体来阻断组胺与受体结合,从而影响变态反应发生的过程。近年来研究发现,抗组胺药可以通过H1受体依赖和非依赖途径起更广泛的抗炎作用,并可以成为反激动剂在组胺缺乏的情况下实施对组胺受体活性的抑制。这些机制促进抗组胺药临床治疗慢性荨麻疹产生新的理念。Antihistamines historically block histamine H1-receptor to prevent the progress of allergic inflammation. The recent sdudies showed that antihistamines also may down-regulate allergic inflammation through both the H1 receptor dependent and non-denpendent ways. It was found that anntihistamines act as inverse agonists to shift the equilibrium toward the inactive state in lack of histamine. Those novel pharmacologic mechanism bring about the new ideas of chronic urticaria.

关 键 词：抗组胺药 慢性荨麻疹 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]