载阿仑膦酸钠超高分子量聚乙烯力学性能研究  

Study on mechanical properties of UHMWPE carrying alendronate

作　　者：屈树新[1,2] 杨丹[1,3] 

机构地区：[1]西南交通大学材料先进技术教育部重点实验室,成都610031 [2]西南交通大学材料科学与工程学院,成都610031 [3]西南交通大学机械工程学院,成都610031

出　　处：《医用生物力学》2009年第5期338-342,共5页Journal of Medical Biomechanics

基　　金：国家自然科学基金资助项目(50535050;50975239);教育部重点资助项目(109137)

摘　　要：目的通过研究载阿仑膦酸钠(ALN)超高分子量聚乙烯(UHMWPE)力学性能,探索载药UHMWPE作为人工关节材料应用的潜能。方法通过热压研制载药质量分数分别为0.25%、0.5%、0.75%和1%的UHMWPE试样作为实验组,未载药UHMWPE作为对照组,分别进行拉伸力学性能测试,小冲杆测试,表面显微硬度测试以及差示扫描量热法(DSC),X射线衍射(XRD)检测。结果加入阿仑膦酸钠对UHMWPE的屈服性能如弹性模量、屈服强度和表面硬度等没有显著影响,但导致UHMWPE的拉伸强度、断裂伸长率和冲击破坏功下降;降低药物浓度时,可减小UHMWPE力学性能的下降;DSC结果表明,药物导致UHMWPE的结晶度下降;XRD结果表明,药物对UHMWPE晶体结构没有影响。结论当阿仑膦酸钠浓度低于0.25%时,可制备与对照组力学性能无显著性差异的载药UHMWPE。阿仑膦酸钠导致UHMWPE结晶度的下降是导致其力学性能下降的主要因素。Objective Aims of this study were to investigate the mechanical properties of Ultra-high molecular weight polyethylene carrying Alendronate（UHMWPE-ALN） and to explore its potential application in clinic. Methods The UHMWPE-ALN samples with 0.25 wt%、 0.5 wt% 、0.75 wt% and1 wt% and the control UHMWPE were prepared by hot-pressure.The tensile test,small punch test,micro hardness,the Differential Scanning Calorimetry（DSC） and X-Ray Diffraction（XRD） were applied to measure the mechanical properties,the crystallinity and the phase of UHMWPE,respectively. Results ALN showed no effect on Young＇s modulus,Yield strength and Hardness of UHMWPE.But its Ultimate elongation,Ultimate strength and Work to failure decreased significantly with adding ALN.DSC and XRD analyses showed that the crystallinity of UHMWPE-ALN decreased slight whereas no phase changes occurred in UHMWPE with added ALN. Conclusion It is feasible to fabricate UHMWPE-ALN with satisfied mechanical properties compared to the control UHMWPE when the content of ALN is lower than 0.25 wt%.The decreased crystallinity of UHMWPE-ALN is the major factor responsible for the decrease in mechanical properties.

关 键 词：超高分子量聚乙烯(UHMWPE) 阿仑膦酸钠 力学性能 

分 类 号：R318.01[医药卫生—生物医学工程]