γ射线辐照交联PVA水凝胶关节软骨修复材料的结构与性能研究  

Preparation and properties of γ-ray radiation crosslinked PVA hydrogel for articular cartilage repair

作　　者：马如银[1] 熊党生[1] 彭艳[1] 金加波[1] Laura McCann Zhongmin Jin John Fisher 

机构地区：[1]南京理工大学材料科学与工程系,南京210094 [2]Institute of Medical and Biological Engineering, School of Mechanical Engineering, The University of Leeds, Leeds, UK, LS2 9JT

出　　处：《医用生物力学》2009年第5期347-351,共5页Journal of Medical Biomechanics

基　　金：国家自然科学基金(50975145);江苏省工业高技术研究计划立项项目(BG2007046);江苏省普通高校研究生科研创新计划项目

摘　　要：目的研究制备工艺对γ射线辐照交联PVA水凝胶关节软骨修复材料的结构与摩擦学性能的影响,为其在关节软骨损伤修复领域的应用提供理论基础。方法采用冷冻解冻和辐照交联相结合的方法制备聚乙烯醇(PVA)水凝胶,研究其微观形貌、含水量及与自然软骨配副的摩擦学性能。结果(1)微观结构的观察表明,制备的PVA水凝胶具有三维多孔网络结构,辐照交联使得网络结构更加致密和完善;(2)水凝胶的含水量随着辐照剂量和PVA浓度的增加而减小;(3)在往复式销-盘摩擦磨损试验机上,研究本水凝胶材料与自然关节软骨配副时的摩擦学性能,结果表明,摩擦的起始阶段,双相润滑机制其主导作用,载荷主要由水凝胶中的液体相所承担,摩擦系数较小,随着载荷作用时间的延长,固体相所承受载荷的比例相对增高,摩擦系数渐渐增大且趋于稳定,润滑机制转为边界润滑。摩擦系数随着辐照剂量和PVA浓度的增加而减小。Objective To study the effect of preparation parameters on structure and friction properties of PVA hydrogels to provid an academic foundation for application potentials of PVA hydrogels in cartilage repair. Method γ-Ray radiation crosslinked PVA hydrogels were prepared by freezing-thawing method combined with irradiation technique,the microstructure and friction properties when sliding against nature articular cartilage were studied. Results （1） SEM observation illustrated that PVA hydrogels had a three-dimensional network structure and such structure became denser after irradiation.（2） Water content of PVA hydrogels decreased with the increasing of irradiation dose and PVA concentration.（3） Friction properties of PVA hydrogels were performed on a reciprocating pin-on-plate machine sliding against nature articular cartilage.The results showed that at shorter loading times,a high proportion of the load was carried by fluid phase which resulted in a lower friction coefficient.As the time extending,more fluid was squeezed away from the contact zone,and the load was transferred to the solid phase of PVA hydrogels,which increased friction coefficient and reached a stable level.Lubrication mechanism transferred from biphasic lubrication to mixed lubrication.Friction coefficients of PVA hydrogels decreased with the increasing of irradiation dose and PVA concentration.

关 键 词：聚乙烯醇水凝胶 软骨修复 摩擦性能 

分 类 号：R318.08[医药卫生—生物医学工程]