犬吉氏巴贝斯虫的人工感染及治疗试验  

Artificial Infection and Treatment Trials on the Canine Babesia gibsoni

作　　者：董君艳[1] 王力光[1] 李忠生[1] 宋珍华[1] 李德昌[2] 陈启军[2] 

机构地区：[1]公安部南京警犬研究所 [2]解放军农牧大学兽医学院

出　　处：《中国兽医学报》1998年第6期563-565,共3页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金

摘　　要：为进一步证实犬吉氏巴贝斯虫（Ｂａｂｅｓｉａｇｉｂｓｏｎｉ）的致病作用，筛选较为理想的治疗药物，将１２只杂种狼犬均分为摘脾组与不摘脾组，进行了吉氏巴贝斯虫人工感染试验。人工感染犬临床症状与自然感染犬无明显差异，表现为体温升高、红细胞减少、Ｈｂ降低及虫血症等，摘脾组较不摘脾组虫血症和症状的出现早１～２ｄ。将此１２只人工感染犬及６７只自然感染犬随机分成４组，分别以贝尼尔（Ｂｅｒｅｎｉｌ）、阿卡普林（Ａ－ｃａｐｒｉｎｕｍ）、蒿甲醚（Ａｒｔｅｍｔｈｅｒｉｎ）和磷酸伯氨喹（Ｐｒｉｍａｑｕｉｎｅｐｈｏｓｐｈａｔｅ）４种药物进行治疗比较试验，结果以蒿甲醚疗效最好，用药后第２天虫体转阴率达７０％，第３天Ｈｂ由２８ｇ／Ｌ上升到６４ｇ／Ｌ，奏效迅速。Twelve hybrid wolfhound were divided equally into two groups, the splenectomized and the unsplenectomized, and artificially infected with Babesia gibsoni to select the ideal drug. The artificially infected canine manifested the same clinical symptoms as naturally infected canine, such as high fever and anemia, except for the earlier (1 2 days) hemosporidemia. The 12 artificially infected and 67 naturally infected canines were divided randomly into 4 groups and treated with berenil, acaprinum, artemtherin and primaquine phosphate separately. The results showed that artemthern is the most effective with the eliminated rate of the hemosporidemia to be up to 70% on the second day after administration and the Hb concentration raising quickly from 28 g/L to 64 g/L.

关 键 词：犬 吉氏巴贝斯虫 人工感染 试验 

分 类 号：S855.9[农业科学—临床兽医学] S858.292.2[农业科学—兽医学]