长托宁和阿托品治疗有机磷中毒的临床疗效对比研究  

Penehyclidine hydrochloride and atropine on organophosphorus poisoning:Results of multicenter,prospective,comparative study

作　　者：何志捷[1] 林小鸿[2] 黄子通[2] 

机构地区：[1]中山大学附属第二医院重症医学科,广东广州510120 [2]中山大学附属第二医院急诊科,广东广州510120

出　　处：《吉林医学》2009年第21期2644-2646,共3页Jilin Medical Journal

摘　　要：目的:探讨长托宁取代阿托品成为抢救有机磷中毒首选药物的可能性。方法:在广东省8家医院展开了前瞻性、多中心、随机、对照研究,比较长托宁和阿托品治疗有机磷中毒的疗效及不良反应。结果:8家医院共180例患者入选,与阿托品组比较,长托宁组患者的用药次数、住院天数显著减少(P<0.01);两组有效率分别为89%和90.1%,两者比较,差异无统计学意义(P>0.05);同一患者治疗前后的心率比较,长托宁组差异无统计学意义(P>0.05),阿托品组差异有统计学意义(P<0.01)。结论:长托宁优于阿托品,可成为抢救有机磷中毒的首选药物。Objective To study the possibility of penehyclidine hydrochloride instead of atropine to be the first choice used in organophosphorus poisoning treatment.Method A multicenter,prospective,comparative clinical research between penehyclidine hydrochloride and atropine on organophosphorus poisoning was made in 8 hospitals,and the effects and adverse effects were compared between the two drugs.Results Total 180 patients with organophosphorus poisoning were randomly divided into 2 groups：Penehyclidine hydroehloride group （ n = 90） and atropine group （ n = 90 ）. The times of administrating drugs and the course of hospitalization in penehyelidine hydroehloride group were less than atropine group（ P 〈 0.01 ）. Both penehyelidine hydroehloride and atropine had positive effect on organophosphorus poisoning. Penehyelidine hydroehloride used conveniently and didn＇t affect HR （P 〉 0.05 ） , while atropine used inconveniently .and affected HR （P 〈 0.01 ）. Conclusion Penehyelidine hydrocbloride is much better than atropine in the treatment of organophosphorus poisoning and can be the first choice.

关 键 词：长托宁 阿托品 有机磷中毒 

分 类 号：R595.4[医药卫生—内科学] R587.2[医药卫生—临床医学]