双二茂铁丙烷哒嗪酮的合成与电化学性质  

Synthesis and Electrochemical Properties of Propyl-bridged Biferrocenyl Substituted Pyridazinone

作　　者：苏爱华[1] 卫兵[2] 李恒东[2] 高勇[2] 袁耀锋[2] 

机构地区：[1]福建卫生职业技术学院医学基础部,福州350101 [2]福州大学化学化工学院,福州350002

出　　处：《福建医科大学学报》2009年第5期384-386,共3页Journal of Fujian Medical University

基　　金：福建省自然科学基金(2006J0112)

摘　　要：目的合成6-双二茂铁丙烷基-4,5-二氢哒嗪-3(2H)-酮,对其电化学性质进行初步研究。方法双二茂铁丙烷先与丁二酸单乙酯酰氯发生酰化反应,生成的1,4-酮酸酯再与水合肼缩合得到含有双二茂铁丙烷的哒嗪酮衍生物。结果通过两步反应合成了6-双二茂铁丙烷基-4,5-二氢哒嗪-3(2H)-酮。结论用IR、MS、1NMR对标题化合物的结构进行了表征。电化学研究表明哒嗪酮基团的引入会对双二茂铁的氧化还原可逆性造成一定的影响。Objective To synthesize 6-propyl-bridged biferrocenyl-4, 5-dihydro-3 （2H）-pyridazi-none and investigate its electrochemical properties. Methods The propyl-bridged biferrocenyl substitu-ted pyridazinone was synthesized by the reaction of propyl-bridged biferrocene with ethyl succinyl chloride, and then condensed with hydrazine hydrate. Results The title compound was synthesized via two-step reaction. Oonclusion The structure of the title compound is characterized by IR, ^1H NMR spectra and MS. The electrochemical behavior of the alkyl-bridged biferrocene is influenced by the introduction of pyr- idazinone heterocycle.

关 键 词：丙烷 亚铁化合物 哒嗪类 电化学 

分 类 号：R91[医药卫生—药学]