克雅病患者脑脊液中细胞因子IL-8的变化  

The change of cytokine IL-8 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease

作　　者：杨蕴天[1] 江新梅[2] 林世和[2] 

机构地区：[1]内蒙古医学院附属第一医院神经内科,呼和浩特010050 [2]吉林大学第一医院神经内科,长春130021

出　　处：《中国人兽共患病学报》2009年第11期1083-1084,共2页Chinese Journal of Zoonoses

基　　金：国家自然科学基金资助课题(30274089)

摘　　要：目的研究克雅病(CJD)患者脑脊液中细胞因子IL-8的水平,探讨趋化性细胞因子在CJD疾病过程中的作用。方法病例分为CJD组、脑炎组和对照组。采用酶联免疫吸附实验检测脑脊液中IL-8的浓度。结果CJD患者脑脊液中IL-8水平明显升高,与对照组相比有统计学意义。结论趋化性细胞因子IL-8在CJD患者脑脊液中含量增加,在其神经变性过程中可能发挥重要的作用。To research the level of cytokine interleukin 8（IL-8） in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease（CJD） and to investigate the potential influence of inflammatory cytokine on the process of CJD.The investigating group composed of patients with CJD,patients with encephalitis and control subjects.and cytokine IL-8 level in CSF were measured with commercial enzyme immunoassay（ELISA）.It was found that the IL-8 level in CSF of CJD patients was significantly higher than that in normal subjects.It is evident that the IL-8 level in CSF of CJD patients was high,suggesting that IL-8 plays important role in the prion disease.

关 键 词：克雅病 细胞因子 白细胞介素8 

分 类 号：R511[医药卫生—内科学]