慢性乙型肝炎外周血HBV—LHBs反式激活功能与抗病毒疗效关系的研究  

Detection of peripheral blood HBV-LHBs transactivation function and its relationship with anti-viral efficacy

作　　者：徐爱芳[1] 陈刚[1] 王妙婵[1] 眭东鸣[1] 朱秀亚[1] 施军平[1] 张永乐[1] 娄国强[1] 

机构地区：[1]杭州市第六人民医院,310014

出　　处：《中华实验和临床病毒学杂志》2009年第5期375-377,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：杭州市医药卫生科技计划项目（2008B053）

摘　　要：目的探究慢性乙型肝炎患者血清中乙型肝炎病毒外膜大蛋白分子（HBV．LHBs）反式激活功能与慢性乙型肝炎抗病毒治疗疗效关系。方法对60例抗病毒治疗的慢性乙型肝炎患者采取每3个月进行HBV DNA、HBV-LHBs以及乙肝免疫标志物检测观察各指标间的变化。结果入组时60例抗病毒组HBVDNA与HBV-LHBs检出率有较高的一致性检出结果，无统计学意义（P〉0．05），HBV—LHBs阳性率与HBeAg阳性率存在差异（χ^2=4．08，P〈0．05）。经过24个月抗病毒治疗HBV-LHBs始终表达者29例，其中HBV DNA在24个月里出现转阴后反弹的20例、HBV DNA持续阳性未转阴者7例。60例患者24个月里未发现HBsAg血清转换，4例出现HBeAg血清转换。结论（1）血清HBV—LHBs检测能够反映出乙肝病毒的复制情况与HBV DNA具有较好的相关性。（2）抗病毒治疗过程中动态观察HBV-LHBs的表达能够预测抗病毒治疗的有效性。Objective Explore the serum of patients with CHB Of HBV large envelope protein （HBV- LHBs）trans-activation function and antiviral therapy effect relationship. Methods 60 cases of anti-viral treatment of patients with chronic hepatitis B to take every 3 months HBVDNA, HBV-LHBs, as well as detection of hepatitis B immune markers to observe the changes in indexes. Results Income group 60 cases of anti-virus group HBVDNA with HBV-LHBs have a higher detection rate of the consistency of the results found no statistical significance （P 〉 0.05）, HBV-LHBs-positive rate and positive rate of HBeAg differences （χ^2 = 4.08, P 〈 0.05）. After 24 months of antiviral therapy HBV-LHBs expression always HBVDNA in 29 cases of which occurred 24 months after the negative reaction of the 20 cases, continuous positive were seven cases of non-negative. 60 cases of patients 24 months found no HBsAg seroeonversion, four cases of emergence of HBeAg seroeonversion. Conclision （1） detection of serum HBV-LHBs to reflect the hepatitis B virus replication with HBVDNA good correlation. （2） anti-viral treatment of dynamic observation of the process of HBV-LHBs expression can predict the effectiveness of anti-viral therapy.

关 键 词：肝炎病毒 乙型 病毒包膜蛋白质类 反式激活(遗传学) 抗病毒药 

分 类 号：R512.62[医药卫生—内科学] R978.7[医药卫生—临床医学]