吡咯喹啉醌研究进展  

Advances on the Research of Pyrroloquinoline Quinone

作　　者：杨璐[1] 熊向华[1] 汪建华[1] 张惟材[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2009年第6期874-879,共6页Letters in Biotechnology

基　　金：国家科技支撑计划(2007BAI46B01)

摘　　要：吡咯喹啉醌(PQQ)是继烟酰胺和黄素核苷酸之后发现的氧化还原酶的第3种辅酶,具有多种生理功能,在食品、医药及农业等行业有广泛的应用前景。我们简要综述了PQQ参与醌酶电子传递、增强微生物对极端环境的适应能力、促进植物生长、刺激神经生长因子生成等生物学功能及相关作用机制,介绍了PQQ生产菌、PQQ合成基因及PQQ生物合成的调控等方面的研究进展。Pyrroloquinoline quinine（PQQ） is the third coenzyme of oxidoreductase, besides NAD and FAD. PQQ owns multiple physiological functions and presents wide application prospect in food industry, pharmaceuticals and agriculture. In this paper, we briefly reviewed the functions of PQQ such as participating in the electron transport, enhancing the adapt- ability of microbes against extreme environments, improving the growth of plants, and stimulating the production of nerve growth factor and its mechanism. The progress of PQQ biosynthesis strains, gene and the regulation mechanism in recent years were also outlined.

关 键 词：吡咯喹啉醌 生理功能 辅酶 生物合成基因 

分 类 号：Q78[生物学—分子生物学]