墨旱莲水煎剂延缓衰老作用的研究  

To Study the Effect of Eclipta Alba Apozem on the Mice Induced Senilily by D-galactose

作　　者：石变华[1] 庄晓燕[2] 白秀珍[2] 

机构地区：[1]长治医学院心血管研究所,046000 [2]辽宁医学院

出　　处：《长治医学院学报》2009年第5期331-333,共3页Journal of Changzhi Medical College

基　　金：辽宁省教育厅资助项目(2021701043)

摘　　要：目的：研究墨旱莲的延缓衰老作用。方法：正常对照组小鼠每日腹腔注射生理盐水1 mg/10g鼠重并同时灌胃与墨旱莲水煎剂等容量的生理盐水;单纯D-半乳糖损伤组小鼠每日腹腔注射与正常组等容量的D-半乳糖1 mg/10 g鼠重并同时灌胃与墨旱莲水煎剂等容量的生理盐水;墨旱莲水煎剂组腹腔注射与正常组等容量的D-半乳糖1 mg/10 g鼠重,同时分别灌胃墨旱莲水煎剂8 mg/g、16 mg/g、32mg/g鼠重。第43 d取材测定SOD、MDA和GSH-PX。结果：与正常对照组相比单纯D-半乳糖损伤组的SOD和GSH-PX活性明显降低,MDA含量明显升高（P〈0.05）;与单纯D-半乳糖损伤组相比墨旱莲水煎剂组SOD和GSH-PX活性明显升高且MDA含量明显降低,并呈剂量依赖性（P〈0.05-P〈0.01）。结论：墨旱莲水煎剂对D-半乳糖致衰老小鼠有延缓衰老作用。Objective：The effect of delaying aging of Eclipta Alba apozem on the mice can be studied. Methods：The mice were divided into five groups and the four groups in them were injected with D - galactose by intraperitoneal every day. And the dosage is 1 mg/ 10 g weight .Another group was the normal one to compare with the four groups.The mice of the normal group were injected with brine by intraperitoneal every day. At the same time the three groups of the four groups were cured with different dosages of Eclipta Alba apozem by lavaging respectively. And the dosages were 8 mg/g, 16 mg/g and 32 mg/g weight. But the other two groups were only lavaged with the brine every day.After forty- two days SOD,GSH- P X and MDA were measured. Results ：Compared with the normal group the activity of SOD and GSH- PX in the mice only injected with D - galactose was obviously lower and the content of MDA was mere（ P 〈 0.05）.compared to the group only injected with D - galactose the activity of SOD and GSH - PX was higher and the content of MDA was less in the mice which took orally Eclipta alba apozem（ P 〈0.05- P 〈0.01）and the result was better when the dosage was bigger in some range. Conclusion：Eclipta alba apozem has the effect of delaying aging to the mice induced senilily by D- galactose.

关 键 词：墨旱莲 衰老 SOD MDA GSH-PX 

分 类 号：R912[医药卫生—药学]