Structural Characteristics and Molecular Mechanism of Hepatitis B Virus Reverse Transcriptase  

作　　者：Hui FENG Kang-hong HU 

机构地区：[1]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071China

出　　处：《Virologica Sinica》2009年第6期509-517,共9页中国病毒学（英文版）

基　　金：National Nature Science Foundations of China (30870131);Program of Chinese Academy of Sciences (0802021SA1)

摘　　要：Hepatitis B virus (HBV), a typical member of the Hepadnaviridae family, is responsible for infections that cause B-type hepatitis which leads to severe public health problems around the world. The small enveloped DNA-containing virus replicates via reverse transcription, and this unique process is accomplished by the virally encoded reverse transcriptase (RT). This multi-functional protein plays a vital role in the viral life cycle. Here, we provide a summary of current knowledge regarding the structural characteristics and molecular mechanisms of HBV RT. Improved understanding of these processes is of both theoretical and practical significance for fundamental studies of HBV and drug discovery.Hepatitis B virus （HBV）, a typical member of the Hepadnaviridae family, is responsible for infections that cause B-type hepatitis which leads to severe public health problems around the world. The small enveloped DNA-containing virus replicates via reverse transcription, and this unique process is accomplished by the virally encoded reverse transcriptase （RT）. This multi-functional protein plays a vital role in the viral life cycle. Here, we provide a summary of current knowledge regarding the structural characteristics and molecular mechanisms of HBV RT. Improved understanding of these processes is of both theoretical and practical significance for fundamental studies of HBV and drug discovery.

关 键 词：HEPADNAVIRUS Hepatitis B virus （HBV） Reverse transcriptase 

分 类 号：Q78[生物学—分子生物学] Q945.11