血清和胸液IFN-γ检测对鉴别结核性和癌性胸液的价值  

The significance of detecting IFN-γ in serum and pleural effusion in differentiating tuberculosis and malignant pleural effusions

作　　者：于俊[1] 王新宁[1] 

机构地区：[1]南京市胸科医院,南京210029

出　　处：《临床肺科杂志》2009年第12期1627-1628,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨血清和胸液IFN-γ检测对鉴别结核性和癌性胸液的价值。方法用酶联免疫吸附试验(ELISA)法分别检测36例结核性胸液(结核组)、20例癌性胸液(肺癌组)及13例漏出液(对照组)患者血清和胸液中IFN-γ水平。结果结核组IFN-γ明显高于肺癌组、对照组(P<0.05),肺癌组与对照组无区别;60岁以下患者血清和胸液IFN-γ浓度结核组高于肺癌组。结论IFN-γ在结核和癌性胸液的者血清和胸液中浓度不同,可作为鉴别诊断的参考依据。Objective To analyze the significance of detecting IFN-γ in serum and pleural effusion in differentiating tuberculosis and nmlignant pleural effusions. Methods The 1 evels of IFN-γ were delected by ELISA in 36 cases of tuberculosis pleural effusion and 20 cases of malignantpleural effusion, and in the serum of 13 cases had pleural effusion due to an etiology otherthantuberculosis or cancer. Results The level of IFN-γ patients with pulmonary tuberculosiswas higher than that ofthe cases with lung cancer or normal controls（P 〈0.05）. in the patients under 60 years old,the levels of IFN-γ in patients with tuberculosis were also higher than those in patients with 1 ung cancer. Conclusion The serum levels of IFN-γ, are different between the patients withpulmonary tuberculosis and with lung cancer,and the detection of them can be used for differential diagnosis.

关 键 词：胸膜疾病 干扰素 

分 类 号：R521.7[医药卫生—内科学] R730.4[医药卫生—临床医学]