麝香保心丸对冠心病血管内皮功能的影响及其作用机制  

Effect of Shexiang Baoxin Pill on endothelial in stable angina pectoris patients and its underlying mechanisms

作　　者：陈焕清[1] 熊小强[1] 段朝晖[1] 赵凤如[1] 韩智娟[1] 张向葵[1] 

机构地区：[1]中山大学附属第二医院,广东广州510120

出　　处：《中成药》2009年第11期1651-1654,共4页Chinese Traditional Patent Medicine

基　　金：广东省科技计划项目(2006B36004007)

摘　　要：目的:探讨麝香保心丸对冠心病患者血管内皮功能的干预及其作用机制。方法:将入选冠心病患者68例随机分成对照组和治疗组,对照组予以冠心病常规治疗,治疗组在常规治疗基础上加用麝香保心丸治疗,疗程3个月,测定治疗前后患者FMD、NO、ET、TXB2、6-Keto-PGF-1 a。结果:治疗结束后,麝香保心丸治疗组FMD、NO、6-Keto-PGF-1 a分别为(9.35%±0.78%)、(77.25±6.36)μmmol/L、(93.87±10.28)ρ/(ng/L),较同组治疗前及对照组治疗后均显著升高(P<0.05);ET、TXB2分别为(81.15±5.43)pg/mL、(43.02±4.19)ρ/(ng/L),较同组治疗前及对照组治疗后均显著降低(P<0.05)。结论:麝香保心丸对老年冠心病患者血管内皮功能具有正性调节作用,其机制可能与纠正ET/NO、TXA2/PG I2的失衡有关。AIM： To investigate the effect of Shexiang Baoxin Pill （SXBXP） on endothelial in stable angina pectoris patients and its underlying mechanisms. METHODS： Sixty-eight stable angina pectoris patients were randomly divided into two groups, the conventional group（34cases）, SXBXP treatment group（34cases）. The conventional group was treated with standard treatment, and SXBXP group was treated with standard treatment and SX- BXP. FMD,NO,ET,TXB2 ,6-Keto-PGF-la were determined before and after three months treatment. RESULTS： FMD,NO,6-Keto-PGF-la of SXBXP group were （9.35% ± 0.78% ）, （77.25 ± 6.36） μmmol/L, （93. 87 ± 10.28 ） p/（ng/L） after treatment, ET, TXB2 were （ 81.15 ± 5.43 ） pg/mL, （43.02 ± 4.19 ） p/（ng/L）. There were significant improvement as compared with in SXBXP group before treatment and in conventional group after treatment（P 〈0.05 ）. CONCLUSION： Shexiang Baoxin Pill plays a positive effect on endothelial in stable angina pectoris patients, its underlying mechanisms may relate to the disbalance of ET/NO and TXB2/PGI2.

关 键 词：麝香保心丸 冠心病 临床研究 血管内皮功能 作用机制 

分 类 号：R287[医药卫生—中药学]